A new study demonstrates that knockdown of miR-193a in human parietal epithelial cells induces their differentiation into podocytes. Inhibition of miR-193a in a model of nephrotoxic nephritis resulted in reduced proteinuria and crescent formation. These data suggest that promoting differentiation of parietal progenitors into podocytes has potential therapeutic relevance.
Podocyte biology: Differentiation of parietal epithelial cells into podocytes / Lazzeri E; Romagnani P.. - In: NATURE REVIEWS. NEPHROLOGY. - ISSN 1759-5061. - ELETTRONICO. - (2015), pp. 7-8.