The manuscript describes the immune suppressive mechanisms of pancreatic cancer (PC) and analyzes the recent preclinical and clinical efforts towards PC immunotherapy, including passive approaches, such as the use of antibodies and active strategies (vaccination), with a special mention of most recent treatment with CRS-207 and GVAX.
Pancreatic cancer: Role of the immune system in cancer progression and vaccine-based immunotherapy / A. Amedei; E. Niccolai; D. Prisco. - In: HUMAN VACCINES & IMMUNOTHERAPEUTICS. - ISSN 2164-5515. - STAMPA. - 10:(2014), pp. 3354-3368. [10.4161/hv.34392]
Pancreatic cancer: Role of the immune system in cancer progression and vaccine-based immunotherapy
AMEDEI, AMEDEO;NICCOLAI, ELENA;PRISCO, DOMENICO
2014
Abstract
The manuscript describes the immune suppressive mechanisms of pancreatic cancer (PC) and analyzes the recent preclinical and clinical efforts towards PC immunotherapy, including passive approaches, such as the use of antibodies and active strategies (vaccination), with a special mention of most recent treatment with CRS-207 and GVAX.
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