In this issue of Blood, is demonstrated that uPAR, the urokinase plasminogen activator (uPA) receptor that drives endothelial invasion and proliferation in the initial phases of angiogenesis, undergoes down-regulation by density-enhanced phosphatase-1 (DEP-1) in confluent endothelial cells.1 Together, uPAR and DEP-1 provide a mechanism that regulates the response of endothelial cells to angiogenic stimuli.
uPAR in angiogenesis regulation / Del Rosso M. - In: BLOOD. - ISSN 0006-4971. - ELETTRONICO. - 117:(2011), pp. 3941-3943. [10.1182/blood-2011-02-337733.]
uPAR in angiogenesis regulation
DEL ROSSO, MARIO
2011
Abstract
In this issue of Blood, is demonstrated that uPAR, the urokinase plasminogen activator (uPA) receptor that drives endothelial invasion and proliferation in the initial phases of angiogenesis, undergoes down-regulation by density-enhanced phosphatase-1 (DEP-1) in confluent endothelial cells.1 Together, uPAR and DEP-1 provide a mechanism that regulates the response of endothelial cells to angiogenic stimuli.
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