This is the first analysis evaluating TOP2A protein by AQUA. This study suggests that evaluation of TOP2A N/C score might be an important step in a multifactorial algorithm predicting sensitivity to anthracyclines
Topoisomerase 2 alpha (TOP2A) protein by automated quantitative analysis (AQUA) as a marker predicting sensitivity to single-agent epirubicin (E) in the neoadjuvant treatment of endocrine-resistant breast cancer (H-BC) / Moretti E; Desmedt C; Biagioni C; Larsimont D; Galardi F; Piccart M; Sotiriou C; Rimm DL; Di Leo A. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - ELETTRONICO. - (2011), pp. ii34-ii34.