We report an innovative approach for the controlled release of DNA, based on clusters of core–shell magnetic nanoparticles. The primary nanoparticles are functionalized with a single-stranded oligonucleotide, whose pairing with a half-complementary strand in solution induces clusterization. The application of a low frequency (6 KHz) alternating magnetic field induces DNA melting with the release of the single strand that induces clusterization.
Magnetic nanoparticle clusters as actuators of ssDNA release / Martina Banchelli; Silvia Nappini; Costanza Montis; Massimo Bonini; Patrizia Canton; Debora Berti; Piero Baglioni. - In: PHYSICAL CHEMISTRY CHEMICAL PHYSICS. - ISSN 1463-9084. - STAMPA. - 16:(2014), pp. 10023-10031. [10.1039/c3cp55470h]
Magnetic nanoparticle clusters as actuators of ssDNA release
BANCHELLI, MARTINA;NAPPINI, SILVIA;MONTIS, COSTANZA;BONINI, MASSIMO;BERTI, DEBORA;BAGLIONI, PIERO
2014
Abstract
We report an innovative approach for the controlled release of DNA, based on clusters of core–shell magnetic nanoparticles. The primary nanoparticles are functionalized with a single-stranded oligonucleotide, whose pairing with a half-complementary strand in solution induces clusterization. The application of a low frequency (6 KHz) alternating magnetic field induces DNA melting with the release of the single strand that induces clusterization.
| File | Dimensione | Formato | |
|---|---|---|---|
|
c3cp55470h.pdf
Accesso chiuso
Tipologia:
Pdf editoriale (Version of record)
Licenza:
Tutti i diritti riservati
Dimensione
2.9 MB
Formato
Adobe PDF
|
2.9 MB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
