In this work a novel self-powered microneedle-based transdermal biosensor for pain-free high-accuracy real-time measurement of glycaemia in interstitial fluid (ISF) is reported.The proposed transdermal biosensor makes use of an array of silicon-dioxide hollow microneedles that are about one order of magnitude both smaller (borehole down to 4μm) and more densely-packed (up to 1×106needles/cm2) than state-of-the-art microneedles used for biosensing so far. This allows self-powered (i.e. pump-free) uptake of ISF to be carried out with high efficacy and reliability in a few seconds (uptake rate up to 1μl/s) by exploiting capillarity in the microneedles. By coupling the microneedles operating under capillary-action with an enzymatic glucose biosensor integrated on the back-side of the needle-chip, glucose measurements are performed with high accuracy (±20% of the actual glucose level for 96% of measures) and reproducibility (coefficient of variation 8.56%) in real-time (30s) over the range 0-630mg/dl, thus significantly improving microneedle-based biosensor performance with respect to the state-of-the-art.
Self-powered microneedle-based biosensors for pain-free high-accuracy measurement of glycaemia in interstitial fluid / L.M. Strambini; A. Longo; S. Scarano; T. Prescimone; I. Palchetti; M. Minunni; D. Giannessi; G. Barillaro. - In: BIOSENSORS & BIOELECTRONICS. - ISSN 0956-5663. - STAMPA. - 66:(2015), pp. 162-168. [10.1016/j.bios.2014.11.010]
Self-powered microneedle-based biosensors for pain-free high-accuracy measurement of glycaemia in interstitial fluid
SCARANO, SIMONA;PALCHETTI, ILARIA;MINUNNI, MARIA;
2015
Abstract
In this work a novel self-powered microneedle-based transdermal biosensor for pain-free high-accuracy real-time measurement of glycaemia in interstitial fluid (ISF) is reported.The proposed transdermal biosensor makes use of an array of silicon-dioxide hollow microneedles that are about one order of magnitude both smaller (borehole down to 4μm) and more densely-packed (up to 1×106needles/cm2) than state-of-the-art microneedles used for biosensing so far. This allows self-powered (i.e. pump-free) uptake of ISF to be carried out with high efficacy and reliability in a few seconds (uptake rate up to 1μl/s) by exploiting capillarity in the microneedles. By coupling the microneedles operating under capillary-action with an enzymatic glucose biosensor integrated on the back-side of the needle-chip, glucose measurements are performed with high accuracy (±20% of the actual glucose level for 96% of measures) and reproducibility (coefficient of variation 8.56%) in real-time (30s) over the range 0-630mg/dl, thus significantly improving microneedle-based biosensor performance with respect to the state-of-the-art.File | Dimensione | Formato | |
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