MicroRNAs (miRNAs) are intensely studied as candidates for diagnostic and prognostic clinical biomarkers. Faradic impedance spectroscopy (EIS) and differential pulse voltammetry (DPV), coupled to disposable gold electrodes and enzyme amplification of the hybridization event, were used for the development of biosensors for the detection of miRNAs. Biotin-labeled liposomes were employed as nanointerfaces that amplify the primary miRNA-sensing events by their association to the probe-/DNA-miRNA-analyte complex generated onto the transducer.
Electrochemical Liposome-Based Biosensors for Nucleic Acid Detection / D Voccia; F Bettazzi; I Palchetti. - STAMPA. - (2014), pp. 179-182. (Intervento presentato al convegno 17th National Conference on Sensors and Microsystems; Brescia; Italy; 5 February 2013 through 7 February 2013;) [10.1007/978-3-319-00684-0_34].
Electrochemical Liposome-Based Biosensors for Nucleic Acid Detection
PALCHETTI, ILARIA
2014
Abstract
MicroRNAs (miRNAs) are intensely studied as candidates for diagnostic and prognostic clinical biomarkers. Faradic impedance spectroscopy (EIS) and differential pulse voltammetry (DPV), coupled to disposable gold electrodes and enzyme amplification of the hybridization event, were used for the development of biosensors for the detection of miRNAs. Biotin-labeled liposomes were employed as nanointerfaces that amplify the primary miRNA-sensing events by their association to the probe-/DNA-miRNA-analyte complex generated onto the transducer.
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