An integrated approach which combines in-cell NMR spectroscopy with optical and X-ray fluorescence microscopy was developed to describe the intracellular maturation state of human Cu,Zn-SOD1. Microscopy data show a correlation between the intracellular levels of SOD1 and the content of zinc, corresponding to zinc binding to SOD1 observed by in-cell NMR.
Combining in-cell NMR and X-ray fluorescence microscopy to reveal the intracellular maturation states of human superoxide dismutase 1 / Enrico Luchinat; Alessandra Gianoncelli; Tommaso Mello; Andrea Galli; Lucia Banci. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 51:(2015), pp. 584-587. [10.1039/c4cc08129c]
Combining in-cell NMR and X-ray fluorescence microscopy to reveal the intracellular maturation states of human superoxide dismutase 1.
LUCHINAT, ENRICO;MELLO, TOMMASO;GALLI, ANDREA;BANCI, LUCIA
2015
Abstract
An integrated approach which combines in-cell NMR spectroscopy with optical and X-ray fluorescence microscopy was developed to describe the intracellular maturation state of human Cu,Zn-SOD1. Microscopy data show a correlation between the intracellular levels of SOD1 and the content of zinc, corresponding to zinc binding to SOD1 observed by in-cell NMR.
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