All biologics are potentially immunogenic and can induce the development of antidrug antibodies (ADAs). ADA formation is associated with lower serum drug levels, infusion reactions, and loss of response. Analytical methods for ADA detection include enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA), surface plasmon resonance, and electrochemiluminescence.
Assays and strategies for immunogenicity assessment of biological agents / Nencini F; Pratesi S; Petroni G; Matucci A; Maggi E; Vultaggio A.. - In: DRUG DEVELOPMENT RESEARCH. - ISSN 0272-4391. - ELETTRONICO. - (2014), pp. s4-s6.
Assays and strategies for immunogenicity assessment of biological agents.
NENCINI, FRANCESCA;PRATESI, SARA;PETRONI, GIULIA;MATUCCI, ANDREA;MAGGI, ENRICO;VULTAGGIO, ALESSANDRA
2014
Abstract
All biologics are potentially immunogenic and can induce the development of antidrug antibodies (ADAs). ADA formation is associated with lower serum drug levels, infusion reactions, and loss of response. Analytical methods for ADA detection include enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA), surface plasmon resonance, and electrochemiluminescence.
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