Adverse drug reactions (ADRs) have become among the most common causes of iatrogenic illness for morbidity and mortality. During the past decade, many new biological agents became available in new therapeutic practices, including cytokines, monoclonal antibodies and fusion proteins. Infliximab is a chimeric monoclonal antibody against TNF-α largely used for the treatment of chronic immuno-mediated diseases such as rheumatoid arthritis, inflammatory bowel diseases, or psoriasis. Infusion reactions have been reported and related to the infliximab immunogenicity and the development of specific IgG and non-IgG antibodies.

Skin testing and infliximab-specific antibodies detection as a combined strategy for preventing infusion reaction / Vultaggio A; Matucci A; Nencini F; Pratesi S; Maggi E.. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - ELETTRONICO. - (2012), pp. s77-s79. [10.1007/s11739-011-0611-x]

Skin testing and infliximab-specific antibodies detection as a combined strategy for preventing infusion reaction.

VULTAGGIO, ALESSANDRA;MATUCCI, ANDREA;NENCINI, FRANCESCA;PRATESI, SARA;MAGGI, ENRICO
2012

Abstract

Adverse drug reactions (ADRs) have become among the most common causes of iatrogenic illness for morbidity and mortality. During the past decade, many new biological agents became available in new therapeutic practices, including cytokines, monoclonal antibodies and fusion proteins. Infliximab is a chimeric monoclonal antibody against TNF-α largely used for the treatment of chronic immuno-mediated diseases such as rheumatoid arthritis, inflammatory bowel diseases, or psoriasis. Infusion reactions have been reported and related to the infliximab immunogenicity and the development of specific IgG and non-IgG antibodies.
2012
s77
s79
Vultaggio A; Matucci A; Nencini F; Pratesi S; Maggi E.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/963003
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