Systemic lupus erythematosus (SLE) is the prototype of autoimmune diseases with multiorgan involvement. SLE presents many genetic and epigenetic associations and the pathogenesis is characterized by a complex network of alterations affecting both adaptative and innate immunity. The disclosure of novel mechanisms of SLE pathogenesis suggested new therapeutic targets, based on interference with the cytokine pathways or on depletion of the immune cells.
Systemic lupus erythematosus: immunopathogenesis and novel therapeutic targets / E. Beccastrini; M.M. D'Elios; G. Emmi; E. Silvestri; D. Squatrito; D. Prisco; L. Emmi. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 26:(2013), pp. 585-596.
Systemic lupus erythematosus: immunopathogenesis and novel therapeutic targets
E. Beccastrini;M. M. D'Elios;G. Emmi;E. Silvestri;D. Squatrito;D. Prisco;
2013
Abstract
Systemic lupus erythematosus (SLE) is the prototype of autoimmune diseases with multiorgan involvement. SLE presents many genetic and epigenetic associations and the pathogenesis is characterized by a complex network of alterations affecting both adaptative and innate immunity. The disclosure of novel mechanisms of SLE pathogenesis suggested new therapeutic targets, based on interference with the cytokine pathways or on depletion of the immune cells.
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