A new NHC iridium(I) complex showing significant antiproliferative properties in vitro is described here. Its crystal structure, solution behaviour and interactions with the model proteins cytochrome c (cyt c) and lysozyme were investigated. High resolution ESI-MS measurements suggest that this iridium(I) complex acts as a prodrug and binds cyt c tightly through an unusual “oxidative” mechanism. Eventually, an iridium(III)-NHC fragment is found associated to the protein
Cytotoxic activity and protein binding through an unusual oxidative mechanism by an iridium(I)–NHC complex / Y. Gothe; T. Marzo; L. Messori; N. Metzler-Nolte. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - ELETTRONICO. - (2015), pp. 3151-3153. [10.1039/C4CC10014J]
Cytotoxic activity and protein binding through an unusual oxidative mechanism by an iridium(I)–NHC complex
MARZO, TIZIANO;MESSORI, LUIGI;
2015
Abstract
A new NHC iridium(I) complex showing significant antiproliferative properties in vitro is described here. Its crystal structure, solution behaviour and interactions with the model proteins cytochrome c (cyt c) and lysozyme were investigated. High resolution ESI-MS measurements suggest that this iridium(I) complex acts as a prodrug and binds cyt c tightly through an unusual “oxidative” mechanism. Eventually, an iridium(III)-NHC fragment is found associated to the protein
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