In human fetal skeletal muscle cells (Hfsmc) tadalafil affected the insulin-related intracellular cascade, by increasing MAPK, PKB/Akt, GSK-3β phosphorylation and c-Myc expression. Free fatty acid release and CS activity also significantly increased, with no changes in SDH activity and lactate release. Tadalafil, like insulin, targeted part of the machinery dedicated to energy management and metabolic control in human skeletal muscle cells
Insulin-like effect of the phosphodiesterase type 5 inhibitor tadalafil onto male human skeletal muscle cells / Crescioli C; Sturli N; Sottili Mariangela; Bonini P; Lenzi A; Di Luigi L.. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - ELETTRONICO. - 36:(2013), pp. 1020-1026. [10.3275/9034]
Insulin-like effect of the phosphodiesterase type 5 inhibitor tadalafil onto male human skeletal muscle cells.
SOTTILI, MARIANGELA;
2013
Abstract
In human fetal skeletal muscle cells (Hfsmc) tadalafil affected the insulin-related intracellular cascade, by increasing MAPK, PKB/Akt, GSK-3β phosphorylation and c-Myc expression. Free fatty acid release and CS activity also significantly increased, with no changes in SDH activity and lactate release. Tadalafil, like insulin, targeted part of the machinery dedicated to energy management and metabolic control in human skeletal muscle cells
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