Abstract BACKGROUND: The Seattle Heart Failure Model (SHFM) is a multimarker risk assessment tool able to predict outcome in heart failure (HF) patients. AIM: To assess whether the SHFM can be used to risk-stratify HF patients who underwent cardiac resynchronization therapy with (CRT-D) or without (CRT) an implantable defibrillator. METHODS AND RESULTS: The SHFM was applied to 342 New York Heart Association class III-IV patients who received a CRT (23%) or CRT-D (77%) device. Discrimination and calibration of SHFM were evaluated through c-statistics and Hosmer-Lemeshow (H-L) goodness-of-fit test. Primary endpoint was a composite of death from any cause/cardiac transplantation. During a median follow-up of 24 months (25th-75th percentile [pct]: 12-37 months), 78 of 342 (22.8%) patients died; seven patients underwent urgent transplantation. Median SHFM score for patients with endpoint was 5.8 years (25th-75th pct: 4.25-8.7 years) versus 8.9 years (25th-75th pct: 6.6-11.8 years) for those without (P < 0.001). Discrimination of SHFM was adequate for the endpoint (c-statistic always ranged around 0.7). The SHFM was a good fit of death from any cause/cardiac transplantation, without significant differences between observed and SHFM-predicted survival. CONCLUSION: The SHFM successfully stratifies HF patients on CRT/CRT-D and can be reliably applied to help clinicians in predicting survival in this clinical setting.

Application of the Seattle Heart Failure Model in patients on cardiac resynchronization therapy / Perrotta L; Ricciardi G; Pieragnoli P; Chiostri M; Pontecorboli G; De Santo T; Bellocci F; Vitulano N; Emdin M; Mascioli G; Ricceri I; Porciani MC; Michelucci A; Padeletti L.. - In: PACING AND CLINICAL ELECTROPHYSIOLOGY. - ISSN 0147-8389. - STAMPA. - (2012), pp. 88-94. [10.1111/j.1540-8159.2011.03258.x]

Application of the Seattle Heart Failure Model in patients on cardiac resynchronization therapy.

PERROTTA, LAURA;RICCIARDI, GIUSEPPE;PIERAGNOLI, PAOLO;CHIOSTRI, MARCO;PONTECORBOLI, GIULIA;RICCERI, ILARIA;PORCIANI, MARIA CRISTINA;MICHELUCCI, ANTONIO;PADELETTI, LUIGI
2012

Abstract

Abstract BACKGROUND: The Seattle Heart Failure Model (SHFM) is a multimarker risk assessment tool able to predict outcome in heart failure (HF) patients. AIM: To assess whether the SHFM can be used to risk-stratify HF patients who underwent cardiac resynchronization therapy with (CRT-D) or without (CRT) an implantable defibrillator. METHODS AND RESULTS: The SHFM was applied to 342 New York Heart Association class III-IV patients who received a CRT (23%) or CRT-D (77%) device. Discrimination and calibration of SHFM were evaluated through c-statistics and Hosmer-Lemeshow (H-L) goodness-of-fit test. Primary endpoint was a composite of death from any cause/cardiac transplantation. During a median follow-up of 24 months (25th-75th percentile [pct]: 12-37 months), 78 of 342 (22.8%) patients died; seven patients underwent urgent transplantation. Median SHFM score for patients with endpoint was 5.8 years (25th-75th pct: 4.25-8.7 years) versus 8.9 years (25th-75th pct: 6.6-11.8 years) for those without (P < 0.001). Discrimination of SHFM was adequate for the endpoint (c-statistic always ranged around 0.7). The SHFM was a good fit of death from any cause/cardiac transplantation, without significant differences between observed and SHFM-predicted survival. CONCLUSION: The SHFM successfully stratifies HF patients on CRT/CRT-D and can be reliably applied to help clinicians in predicting survival in this clinical setting.
2012
88
94
Perrotta L; Ricciardi G; Pieragnoli P; Chiostri M; Pontecorboli G; De Santo T; Bellocci F; Vitulano N; Emdin M; Mascioli G; Ricceri I; Porciani MC; Mi...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/969646
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