Tuberculin skin test, QuantiFERON-TB Gold In-Tube and T-SPOT.TB were performed in 338 children at risk for tuberculosis (TB), including 70 active TB cases. In children <5 years of age, QuantiFERON-TB Gold In-Tube sensitiv- ity was 73.3% [95% confidence interval (CI): 57.5–89.1]; and T-SPOT.TB sensi- tivity was 59.3% (95% CI: 40.1–77.8); both were inferior to tuberculin skin test sensitivity (90.0%; 95% CI: 79.3–100). In children ≥5 years QuantiFERON-TB Gold In-Tube sensitivity was 92.5% (95% CI: 84.4–100); T-SPOT.TB sensitivity was 73.0% (95% CI: 58.6–87.3) ; and tuberculin skin test sensitivity was 97.5% (95% CI: 92.6–100).Test specificities were similar in all age groups.

Interferon-gamma release assay sensitivity in children younger than 5 years is insufficient to replace the use of tuberculin skin test in western countries / Elena Chiappini; Bonsignori F; Mazzantini R; Sollai S; Venturini E; Giusi Mangone; Martina Cortimiglia; Olivito B; Chiara Azzari; Luisa Galli; Maurizio de Martino. - In: THE PEDIATRIC INFECTIOUS DISEASE JOURNAL. - ISSN 0891-3668. - STAMPA. - 33:(2014), pp. 1291-1293. [10.1097/INF.0000000000000432]

Interferon-gamma release assay sensitivity in children younger than 5 years is insufficient to replace the use of tuberculin skin test in western countries

CHIAPPINI, ELENA;MANGONE, GIUSI;CORTIMIGLIA, MARTINA;AZZARI, CHIARA;GALLI, LUISA;DE MARTINO, MAURIZIO
2014

Abstract

Tuberculin skin test, QuantiFERON-TB Gold In-Tube and T-SPOT.TB were performed in 338 children at risk for tuberculosis (TB), including 70 active TB cases. In children <5 years of age, QuantiFERON-TB Gold In-Tube sensitiv- ity was 73.3% [95% confidence interval (CI): 57.5–89.1]; and T-SPOT.TB sensi- tivity was 59.3% (95% CI: 40.1–77.8); both were inferior to tuberculin skin test sensitivity (90.0%; 95% CI: 79.3–100). In children ≥5 years QuantiFERON-TB Gold In-Tube sensitivity was 92.5% (95% CI: 84.4–100); T-SPOT.TB sensitivity was 73.0% (95% CI: 58.6–87.3) ; and tuberculin skin test sensitivity was 97.5% (95% CI: 92.6–100).Test specificities were similar in all age groups.
2014
33
1291
1293
Elena Chiappini; Bonsignori F; Mazzantini R; Sollai S; Venturini E; Giusi Mangone; Martina Cortimiglia; Olivito B; Chiara Azzari; Luisa Galli; Maurizi...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/971418
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