Glutamine synthetase is an enzyme involved in the clearance of glutamate, the most potent excitatory neurotransmitter. We studied the immunohistochemical expression of glutamine synthetase in neocortical samples from 5 children who underwent surgery for pharmacoresistant epilepsy and a histological diagnosis of focal cortical dysplasia IIb. In all cases, balloon cells, but not dysmorphic neurons, were immunopositive for glutamine synthetase. This finding suggests that balloon cells can be involved in the neutralization of glutamate and play a protective anti-seizure role.
Expression of glutamine synthetase in balloon cells: a basis of their antiepileptic role? / Buccoliero AM; Barba C; Giordano F; Baroni G; Genitori L; Guerrini R; Taddei GL.. - In: CLINICAL NEUROPATHOLOGY. - ISSN 0722-5091. - STAMPA. - (2015), pp. 83-88.
Expression of glutamine synthetase in balloon cells: a basis of their antiepileptic role?
Barba C;Giordano F;GUERRINI, RENZO;
2015
Abstract
Glutamine synthetase is an enzyme involved in the clearance of glutamate, the most potent excitatory neurotransmitter. We studied the immunohistochemical expression of glutamine synthetase in neocortical samples from 5 children who underwent surgery for pharmacoresistant epilepsy and a histological diagnosis of focal cortical dysplasia IIb. In all cases, balloon cells, but not dysmorphic neurons, were immunopositive for glutamine synthetase. This finding suggests that balloon cells can be involved in the neutralization of glutamate and play a protective anti-seizure role.
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