GENOVESE, MASSIMO

GENOVESE, MASSIMO  

Scienze Biomediche, Sperimentali e Cliniche 'Mario Serio'  

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A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties 2024 Paoli Paolo, Massimo Genovese, Lucia Pecora
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity 2022 Sblano S.; Cerchia C.; Laghezza A.; Piemontese L.; Brunetti L.; Leuci R.; Gilardi F.; Thomas A.; Genovese M.; Santi A.; Tortorella P.; Paoli P.; Lavecchia A.; Loiodice F.
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 2023 Laghezza A.; Cerchia C.; Genovese M.; Leuci R.; Pranzini E.; Santi A.; Brunetti L.; Piemontese L.; Tortorella P.; Biswas A.; Singh R.P.; Tambe S.; Ca S.; Pattnaik A.K.; Jayaprakash V.; Paoli P.; Lavecchia A.; Loiodice F.
Designed multiple ligands for the treatment of type 2 diabetes mellitus and its complications: Discovery of (5-arylidene-4-oxo-2-thioxothiazolidin-3-yl)alkanoic acids active as novel dual-targeted PTP1B/AKR1B1 inhibitors 2023 Maccari R.; Wolber G.; Genovese M.; Sardelli G.; Talagayev V.; Balestri F.; Luti S.; Santi A.; Moschini R.; Del Corso A.; Paoli P.; Ottana R.
Evidence of Insulin-Sensitizing and Mimetic Activity of the Sesquiterpene Quinone Avarone, a Protein Tyrosine Phosphatase 1B and Aldose Reductase Dual Targeting Agent from the Marine Sponge Dysidea avara 2023 Casertano M.; Genovese M.; Santi A.; Pranzini E.; Balestri F.; Piazza L.; Del Corso A.; Avunduk S.; Imperatore C.; Menna M.; Paoli P.
Identifying Human PTP1B Enzyme Inhibitors from Marine Natural Products: Perspectives for Developing of Novel Insulin-Mimetic Drugs 2022 Casertano M.; Genovese M.; Piazza L.; Balestri F.; Del Corso A.; Vito A.; Paoli P.; Santi A.; Imperatore C.; Menna M.
In search for multi-target ligands as potential agents for diabetes mellitus and its complications—a structure-activity relationship study on inhibitors of aldose reductase and protein tyrosine phosphatase 1b 2021 Rosaria Ottanà, Paolo Paoli, Mario Cappiello, Trung Ngoc Nguyen, Ilenia Adornato, Antonella Del Corso, Massimo Genovese, Ilaria Nesi, Roberta Moschini, Alexandra Naß, GerhardWolber and Rosanna Maccari,
Rational design and synthesis of novel N-benzylindole-based epalrestat analogs as selective aldose reductase inhibitors: An unexpected discovery of a new glucose-lowering agent (AK-4) acting as a mitochondrial uncoupler 2024 Paoli Paolo, Alice Santi, Massimo Genovese
Rumen microbial community and milk quality in Holstein lactating cows fed olive oil pomace as part in a sustainable feeding strategy 2023 F. Scicutella, M.A. Cucu, F. Mannelli, R. Pastorelli, M. Daghio, P. Paoli c , L. Pazzagli, L. Turini, A. Mantino, S. Luti, M. Genovese, C. Viti, A. Buccioni
Studying the trafficking of labeled trodusquemine and its application as nerve marker for light-sheet and expansion microscopy 2022 Claudia Capitini, Luca Pesce, Giulia Fani, Giacomo Mazzamuto, Massimo Genovese, Alessandra Franceschini, Paolo Paoli, Giuseppe Pieraccini, Michael Zasloff, Fabrizio Chiti, Francesco S Pavone, Martino Calamai
Targeting of tumor cells by custom antigen transfer: a novel approach for immunotherapy of cancer 2023 Nesi, Ilaria; Della Bella, Chiara; Taddei, Maria Letizia; Santi, Alice; Pranzini, Erica; Paoli, Paolo; D'Elios, Mario Milco; Ramazzotti, Matteo; Genovese, Massimo; Caselli, Anna; Cirri, Paolo