| Nome |
# |
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Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors., file e398c37b-7357-179a-e053-3705fe0a4cff
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386
|
|
Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects., file e398c37d-b0ce-179a-e053-3705fe0a4cff
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273
|
|
Syntesis of thio- and seleno-acetamides bearing benzenesulfonamide as potent inhibitors of human carbonic anhydrase II and XII, file e398c37e-5dcd-179a-e053-3705fe0a4cff
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251
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Sulfur, selenium and tellurium containing amines act as effective carbonic
anhydrase activators, file e398c37e-4256-179a-e053-3705fe0a4cff
|
234
|
|
Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX), file e398c380-cf03-179a-e053-3705fe0a4cff
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231
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Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines, file e398c37d-6ca7-179a-e053-3705fe0a4cff
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222
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Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology, file e398c37d-6ae5-179a-e053-3705fe0a4cff
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168
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Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors, file e398c380-c5fe-179a-e053-3705fe0a4cff
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157
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Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition, file e398c381-d57a-179a-e053-3705fe0a4cff
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152
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From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction, file e398c380-cdc3-179a-e053-3705fe0a4cff
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137
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Sulfonamide inhibition studies of an α-carbonic anhydrase from Schistosoma mansoni, a platyhelminth parasite responsible for schistosomiasis, file e398c37f-5f04-179a-e053-3705fe0a4cff
|
109
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Benzylaminoethyureido-Tailed Benzenesulfonamides: Design, Synthesis, Kinetic and X-ray Investigations on Human Carbonic Anhydrases, file e398c37f-7d59-179a-e053-3705fe0a4cff
|
100
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Evaluation of Thio- and Seleno-Acetamides Bearing Benzenesulfonamide as Inhibitor of Carbonic Anhydrases from Different Pathogenic Bacteria, file e398c37f-540e-179a-e053-3705fe0a4cff
|
80
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New β-arylchalcogeno amines with procognitive properties targeting Carbonic Anhydrases and Monoamine Oxidases, file a964fccc-21e4-441a-aa6d-1d87e4da5669
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76
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Ionic liquids as an alternative reaction medium for HMDST based synthesis of thioaldehydes, file e398c37a-49db-179a-e053-3705fe0a4cff
|
76
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Activation Effects of Carnosine- and Histidine-Containing Dipeptides on Human Carbonic Anhydrases: A Comprehensive Study, file e398c37f-7b92-179a-e053-3705fe0a4cff
|
73
|
|
First evaluation of organotellurium derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors, file e398c381-9494-179a-e053-3705fe0a4cff
|
72
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Activation of β- and γ-carbonic anhydrases from pathogenic bacteria with tripeptides, file e398c37f-33d0-179a-e053-3705fe0a4cff
|
71
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Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides, file e398c37f-546b-179a-e053-3705fe0a4cff
|
68
|
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Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold, file e398c37f-1138-179a-e053-3705fe0a4cff
|
65
|
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Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine, file e398c37f-8357-179a-e053-3705fe0a4cff
|
65
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Synthesis, biological activity and multiscale molecular modeling studies for coumaryl-carboxamide derivatives as selective carbonic anhydrase IX inhibitors, file e398c37f-59de-179a-e053-3705fe0a4cff
|
58
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Inhibition of the α-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties, file e398c37f-33cb-179a-e053-3705fe0a4cff
|
57
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Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases, file e398c37f-113d-179a-e053-3705fe0a4cff
|
56
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Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry, file e398c381-81db-179a-e053-3705fe0a4cff
|
56
|
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Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators, file e398c380-1ec8-179a-e053-3705fe0a4cff
|
54
|
|
Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX), file e398c380-fa16-179a-e053-3705fe0a4cff
|
50
|
|
New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators, file e398c381-fdd9-179a-e053-3705fe0a4cff
|
49
|
|
Activation studies of the γ-carbonic anhydrases from the antarctic marine bacteria pseudoalteromonas haloplanktis and colwellia psychrerythraea with amino acids and amines, file e398c37f-deb8-179a-e053-3705fe0a4cff
|
45
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Selenocarbamates As a Prodrug-Based Approach to Carbonic Anhydrase Inhibition, file c0480e28-192b-4b38-940f-40b8295570e0
|
26
|
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Synthesis, characterization, biological assays and development of new enzyme modulators for the treatment of human pathologies, file e398c37e-1bdb-179a-e053-3705fe0a4cff
|
22
|
|
Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors, file 2bec5184-c58a-4a4a-af68-2fac21d901a3
|
20
|
|
Novel 2-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)-1-(1,3,5-triazin-2-ylamino)guanidine derivatives: Inhibition of human carbonic anhydrase cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII, anticancer activity, and molecular modeling studies, file e398c381-1edc-179a-e053-3705fe0a4cff
|
16
|
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Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII, file e398c380-cb02-179a-e053-3705fe0a4cff
|
15
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3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII, file e398c382-2dd7-179a-e053-3705fe0a4cff
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11
|
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Mono- and three-tailed sugar and iminosugar decorated benzenesulfonamide carbonic anhydrase inhibitors, file d2ed2546-9adb-43dd-a851-64f1f1af7262
|
8
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Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors, file 467126b4-9137-41e4-8b4c-1c0067907492
|
6
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Lipoyl-Based Antagonists of Transient Receptor Potential Cation A (TRPA1) Downregulate Osteosarcoma Cell Migration and Expression of Pro-Inflammatory Cytokines, file 7f85c141-eef0-4787-90c7-5d0cf5cf502a
|
5
|
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Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII, file e398c37c-e83b-179a-e053-3705fe0a4cff
|
4
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Polypharmacology of epacadostat: A potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII, file e398c37e-50c0-179a-e053-3705fe0a4cff
|
4
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3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII, file e398c37c-220c-179a-e053-3705fe0a4cff
|
3
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Synthesis of N′-phenyl-N-hydroxyureas and investigation of their inhibitory activities on human carbonic anhydrases, file e398c37f-06f8-179a-e053-3705fe0a4cff
|
3
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Synthesis of Azasugar–Sulfonamide conjugates and their Evaluation as Inhibitors of Carbonic Anhydrases: the Azasugar Approach to Selectivity, file e398c381-8331-179a-e053-3705fe0a4cff
|
3
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Azidothymidine "clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors, file 613729c2-b6e3-4baa-8440-cbd1b31bce0b
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2
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Synthesis and Biological Evaluation of Imidazo[2 ,1-b]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors, file d30547bd-f007-4670-a3ac-19cdebf8cca2
|
2
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|
Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors, file e398c37b-abff-179a-e053-3705fe0a4cff
|
2
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Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors, file e398c37e-f3a3-179a-e053-3705fe0a4cff
|
2
|
|
Novel 2-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)-1-(1,3,5-triazin-2-ylamino)guanidine derivatives: Inhibition of human carbonic anhydrase cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII, anticancer activity, and molecular modeling studies, file e398c37f-0f90-179a-e053-3705fe0a4cff
|
2
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Activation studies with amines and amino acids of the α-carbonic anhydrase from the pathogenic protozoan Trypanosoma cruzi, file e398c37f-3afe-179a-e053-3705fe0a4cff
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2
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Chagas Disease: Perspectives on the Past and Present and Challenges in Drug Discovery, file 019862f9-fe5e-4b0d-84b5-a0593c58c40f
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1
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Crystal structure of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium burkholderia pseudomallei, file 95805aa6-ff85-4329-a0a1-4fb2ea18170b
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1
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Seleno Containing Compounds as Potent and Selective Antifungal Agents, file acf5e20c-5bda-4af0-a3fc-309551341e59
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1
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Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment, file c21d4ba2-0863-4fca-9ee1-bc237667b106
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1
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Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies, file cbe1270c-71b5-4a5d-873c-b72d88c91a78
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1
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Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties, file e398c37c-d717-179a-e053-3705fe0a4cff
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1
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Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors, file e398c37e-937c-179a-e053-3705fe0a4cff
|
1
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Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases, file e398c37e-f3a8-179a-e053-3705fe0a4cff
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1
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New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors, file e398c37e-f3ac-179a-e053-3705fe0a4cff
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1
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Prostaglandin receptor agonists as antiglaucoma agents (a patent review 2013–2018), file e398c37e-f6ba-179a-e053-3705fe0a4cff
|
1
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|
Targeting Tumor Associated Carbonic Anhydrases IX and XII: Highly Isozyme Selective Coumarin and Psoralen Inhibitors, file e398c37f-01b7-179a-e053-3705fe0a4cff
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1
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The zinc – but not cadmium – containing ζ-carbonic from the diatom Thalassiosira weissflogii is potently activated by amines and amino acids, file e398c37f-01b8-179a-e053-3705fe0a4cff
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1
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Synthesis and biological evaluation of coumarin-1,3,4-oxadiazole hybrids as selective carbonic anhydrase IX and XII inhibitors, file e398c37f-01bb-179a-e053-3705fe0a4cff
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1
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Synthesis, biological evaluation and in silico modelling studies of 1,3,5-trisubstituted pyrazoles carrying benzenesulfonamide as potential anticancer agents and selective cancer-associated hCA IX isoenzyme inhibitors, file e398c37f-01be-179a-e053-3705fe0a4cff
|
1
|
|
An efficient method for the synthesis of novel derivatives 4-5-[4-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)-phenyl]-3-trifluoromethyl-pyrazol-1-yl-benzenesulfonamide and their anti-inflammatory potential, file e398c37f-18bb-179a-e053-3705fe0a4cff
|
1
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|
Anion inhibition profile of the β-carbonic anhydrase from the opportunist pathogenic fungus malassezia restricta involved in dandruff and seborrheic dermatitis, file e398c37f-18be-179a-e053-3705fe0a4cff
|
1
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Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA, file e398c37f-33ce-179a-e053-3705fe0a4cff
|
1
|
|
Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies, file e398c37f-393d-179a-e053-3705fe0a4cff
|
1
|
|
Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma, file e398c37f-393f-179a-e053-3705fe0a4cff
|
1
|
|
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety, file e398c37f-3af9-179a-e053-3705fe0a4cff
|
1
|
|
N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms, file e398c37f-3b00-179a-e053-3705fe0a4cff
|
1
|
|
Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides, file e398c37f-3b01-179a-e053-3705fe0a4cff
|
1
|
|
Sulfonamide Inhibition Profile of the β-Carbonic Anhydrase from Malassezia restricta, An Opportunistic Pathogen Triggering Scalp Conditions, file e398c37f-540b-179a-e053-3705fe0a4cff
|
1
|
|
Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases, file e398c37f-546d-179a-e053-3705fe0a4cff
|
1
|
|
Synthesis and exploration of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives for their effects against carbonic anhydrase I, II, IX and XII isoforms as a non-sulfonamide class of inhibitors, file e398c37f-555c-179a-e053-3705fe0a4cff
|
1
|
|
Treatment of sleep apnea with a combination of a carbonic anhydrase inhibitor and an aldosterone antagonist: a patent evaluation of CA2958110 and IN6616DEN2012, file e398c37f-555e-179a-e053-3705fe0a4cff
|
1
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|
A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction, file e398c37f-59df-179a-e053-3705fe0a4cff
|
1
|
|
Novel sulfonamides incorporating 1,3,5-triazine and amino acid structural motifs as inhibitors of the physiological carbonic anhydrase isozymes I, II and IV and tumor-associated isozyme IX, file e398c37f-59e1-179a-e053-3705fe0a4cff
|
1
|
|
Synthesis of Novel Selenides Bearing Benzenesulfonamide Moieties as Carbonic Anhydrase I, II, IV, VII, and IX Inhibitors, file e398c380-c6da-179a-e053-3705fe0a4cff
|
1
|
|
Selenols: a new class of carbonic anhydrase inhibitors, file e398c380-dd3a-179a-e053-3705fe0a4cff
|
1
|
|
Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity, file e398c380-fa89-179a-e053-3705fe0a4cff
|
1
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| Totale |
3.680 |