BIGI, ALESSANDRA
BIGI, ALESSANDRA
Scienze Biomediche, Sperimentali e Cliniche 'Mario Serio'
A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43
2022 Roberta Cascella, Alessandra Bigi, Dylan Giorgino Riffert, Maria Cristina Gagliani, Emilio Ermini, Matteo Moretti, Katia Cortese, Cristina Cecchi, Fabrizio Chiti
A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer's disease CSF
2024 Alessandra Bigi, Liliana Napolitano, Devkee M. Vadukul, Fabrizio Chiti, Cristina Cecchi, Francesco A. Aprile, Roberta Cascella
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases
2022 Alessandra Bigi, Roberta Cascella, Fabrizio Chiti, Cristina Cecchi
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature
2023 Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature
2023 Cascella R, Banchelli M, Abolghasem Ghadami S, Ami D, Gagliani MC, Bigi A, Staderini T, Tampellini D, Cortese K, Cecchi C, Natalello A, Adibi H, Matteini P, Chiti F.
APP and Bace1: Differential effect of cholesterol enrichment on processing and plasma membrane mobility
2023 Claudia Capitini, Alessandra Bigi, Niccolò Parenti, Marco Emanuele, Niccolò Bianchi, Roberta Cascella, Cristina Cecchi, Laura Maggi, Francesco Annunziato, Francesco Saverio Pavone, Martino Calamai
Biophysical characterization of full-length TAR DNA-binding protein (TDP-43) phase separation.
2022 Tommaso Staderini, Alessandra Bigi, Daniele Mongiello, Cristina Cecchi, Fabrizio Chiti
Editorial: Promising therapeutic strategies for Alzheimer’s disease: a focus on amyloid-β targeting
2024 Alessandra Bigi, Ryan Limbocker, Cristina Cecchi
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies
2022 Roberta Cascella, Alessandra Bigi, Nunilo Cremades, Cristina Cecchi
Exploring the release of toxic oligomers from α-synuclein fibrils with antibodies and sted microscopy
2021 Bigi A.; Ermini E.; Chen S.W.; Cascella R.; Cecchi C.
Identification of Novel 1,3,5-Triphenylbenzene Derivative Compounds as Inhibitors of Hen Lysozyme Amyloid Fibril Formation
2019 Hassan Ramshini , Reza Tayebee, Alessandra Bigi, Francesco Bemporad, Cristina Cecchi, Fabrizio Chiti
Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases
2019 Cascella R, Fani G, Bigi A, Chiti F, Cecchi C.
Putative novel CSF biomarkers of Alzheimer’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort
2024 Bigi, Alessandra; Fani, Giulia; Bessi, Valentina; Napolitano, Liliana; Bagnoli, Silvia; Ingannato, Assunta; Neri, Lorenzo; Cascella, Roberta; Matteini, Paolo; Sorbi, Sandro; Nacmias, Benedetta; Cecchi, Cristina; Chiti, Fabrizio
Secreted sphingosine 1-phosphate exerts a novel autocrine action in bone marrow-derived mesenchymal stromal cell signalling
2016 Pierucci, F; Sassoli, C; Tani, A; Frati, A; Bigi, A; Chellini, F; Matteini, F; Anderloni, G; Nosi, D; Mazzanti, B; Zecchi-Orlandini, S; Meacci, E
Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload
2017 Cascella, Roberta; Evangelisti, Elisa; Bigi, Alessandra; Becatti, Matteo; Fiorillo, Claudia; Stefani, Massimo; Chiti, Fabrizio; Cecchi, Cristina
Sphingosine 1-phosphate attenuates neuronal dysfunction induced by amyloid-β oligomers through endocytic internalization of NMDA receptors
2023 Bigi A, Cascella R, Fani G, Bernacchioni C, Cencetti F, Bruni P, Chiti F, Donati C, Cecchi C.
Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers
2021 Ryan Limbocker, Roxine Staats, Sean Chia, Francesco S Ruggeri, Benedetta Mannini, Catherine K Xu, Michele Perni, Roberta Cascella, Alessandra Bigi, Liam R Sasser, Natalie R Block, Aidan K Wright, Ryan P Kreiser, Edward T Custy, Georg Meisl, Silvia Errico, Johnny Habchi, Patrick Flagmeier, Tadas Kartanas, Jared E Hollows, Lam T Nguyen, Kathleen LeForte, Denise Barbut, Janet R Kumita, Cristina Cecchi, Michael Zasloff, Tuomas P J Knowles, Christopher M Dobson, Fabrizio Chiti, Michele Vendruscolo
Structure-toxicity relationship in intermediate fibrils from lα-Synuclein condensates
2024 Serene W. Chen, Joseph D. Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A. Jarvis, Fabrizio Chiti, Christopher M. Dobson, Giuliana Fusco, and Alfonso De Simone
Study of the relationship between structure and toxicity of different α-synuclein aggregates and related cellular dysfunctions
2020 Alessandra Bigi
Targeting pathological amyloid aggregates with conformation-sensitive antibodies
2020 Alessandra Bigi, Gilda Loffredo, Roberta Cascella, Cristina Cecchi
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43 | 2022 | Roberta Cascella, Alessandra Bigi, Dylan Giorgino Riffert, Maria Cristina Gagliani, Emilio Ermini, Matteo Moretti, Katia Cortese, Cristina Cecchi, Fabrizio Chiti | |
| A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer's disease CSF | 2024 | Alessandra Bigi, Liliana Napolitano, Devkee M. Vadukul, Fabrizio Chiti, Cristina Cecchi, Francesco A. Aprile, Roberta Cascella | |
| Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases | 2022 | Alessandra Bigi, Roberta Cascella, Fabrizio Chiti, Cristina Cecchi | |
| An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature | 2023 | Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti | |
| An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature | 2023 | Cascella R, Banchelli M, Abolghasem Ghadami S, Ami D, Gagliani MC, Bigi A, Staderini T, Tampellini D, Cortese K, Cecchi C, Natalello A, Adibi H, Matteini P, Chiti F. | |
| APP and Bace1: Differential effect of cholesterol enrichment on processing and plasma membrane mobility | 2023 | Claudia Capitini, Alessandra Bigi, Niccolò Parenti, Marco Emanuele, Niccolò Bianchi, Roberta Cascella, Cristina Cecchi, Laura Maggi, Francesco Annunziato, Francesco Saverio Pavone, Martino Calamai | |
| Biophysical characterization of full-length TAR DNA-binding protein (TDP-43) phase separation. | 2022 | Tommaso Staderini, Alessandra Bigi, Daniele Mongiello, Cristina Cecchi, Fabrizio Chiti | |
| Editorial: Promising therapeutic strategies for Alzheimer’s disease: a focus on amyloid-β targeting | 2024 | Alessandra Bigi, Ryan Limbocker, Cristina Cecchi | |
| Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies | 2022 | Roberta Cascella, Alessandra Bigi, Nunilo Cremades, Cristina Cecchi | |
| Exploring the release of toxic oligomers from α-synuclein fibrils with antibodies and sted microscopy | 2021 | Bigi A.; Ermini E.; Chen S.W.; Cascella R.; Cecchi C. | |
| Identification of Novel 1,3,5-Triphenylbenzene Derivative Compounds as Inhibitors of Hen Lysozyme Amyloid Fibril Formation | 2019 | Hassan Ramshini , Reza Tayebee, Alessandra Bigi, Francesco Bemporad, Cristina Cecchi, Fabrizio Chiti | |
| Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases | 2019 | Cascella R, Fani G, Bigi A, Chiti F, Cecchi C. | |
| Putative novel CSF biomarkers of Alzheimer’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort | 2024 | Bigi, Alessandra; Fani, Giulia; Bessi, Valentina; Napolitano, Liliana; Bagnoli, Silvia; Ingannato, Assunta; Neri, Lorenzo; Cascella, Roberta; Matteini, Paolo; Sorbi, Sandro; Nacmias, Benedetta; Cecchi, Cristina; Chiti, Fabrizio | |
| Secreted sphingosine 1-phosphate exerts a novel autocrine action in bone marrow-derived mesenchymal stromal cell signalling | 2016 | Pierucci, F; Sassoli, C; Tani, A; Frati, A; Bigi, A; Chellini, F; Matteini, F; Anderloni, G; Nosi, D; Mazzanti, B; Zecchi-Orlandini, S; Meacci, E | |
| Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload | 2017 | Cascella, Roberta; Evangelisti, Elisa; Bigi, Alessandra; Becatti, Matteo; Fiorillo, Claudia; Stefani, Massimo; Chiti, Fabrizio; Cecchi, Cristina | |
| Sphingosine 1-phosphate attenuates neuronal dysfunction induced by amyloid-β oligomers through endocytic internalization of NMDA receptors | 2023 | Bigi A, Cascella R, Fani G, Bernacchioni C, Cencetti F, Bruni P, Chiti F, Donati C, Cecchi C. | |
| Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers | 2021 | Ryan Limbocker, Roxine Staats, Sean Chia, Francesco S Ruggeri, Benedetta Mannini, Catherine K Xu, Michele Perni, Roberta Cascella, Alessandra Bigi, Liam R Sasser, Natalie R Block, Aidan K Wright, Ryan P Kreiser, Edward T Custy, Georg Meisl, Silvia Errico, Johnny Habchi, Patrick Flagmeier, Tadas Kartanas, Jared E Hollows, Lam T Nguyen, Kathleen LeForte, Denise Barbut, Janet R Kumita, Cristina Cecchi, Michael Zasloff, Tuomas P J Knowles, Christopher M Dobson, Fabrizio Chiti, Michele Vendruscolo | |
| Structure-toxicity relationship in intermediate fibrils from lα-Synuclein condensates | 2024 | Serene W. Chen, Joseph D. Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A. Jarvis, Fabrizio Chiti, Christopher M. Dobson, Giuliana Fusco, and Alfonso De Simone | |
| Study of the relationship between structure and toxicity of different α-synuclein aggregates and related cellular dysfunctions | 2020 | Alessandra Bigi | |
| Targeting pathological amyloid aggregates with conformation-sensitive antibodies | 2020 | Alessandra Bigi, Gilda Loffredo, Roberta Cascella, Cristina Cecchi |