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8a - Tesi di dottorato 3760

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Brain-wide mapping of the full, intact mouse brain with micrometre-scale resolution: Enhanced expansion microscopy and light-sheet microscopy for large tissue applications

At the very basis of all physiological research is the ability to image the anatomy of the tissue in question, facilitated by the tools available. Each organ system has its own defined structure corresponding to its functionality which gives rise to the need to image these systems in an unbiased and complete manner. Analysing large volumes of organ tissue, however, remains a palpable challenge within science. Despite the variety of sample preparation and imaging techniques, many require c...

Development of an optical system for three-dimensional multicolour super-resolution microscopy and its application to the study of subcellular compartmentalization

Over the last decades, super-resolution techniques have completely revolutionized the world of microscopy and have become increasingly relevant for the biological research by enabling the observation of unresolved details of cellular structures and by elucidating many biological processes at the molecular scale. However, there are still some challenges to be faced. Currently, performing multicolour super-resolution imaging is not trivial. In particular, fine correction of all potential aberra...

Un sistema multilivello per migliorare la conoscenza della terapia farmacologica tra le donne in età fertile, nella gravidanza e nel post-parto usando applicazioni di serious gaming

Introduzione e scopo della ricerca: L'aderenza e corretta gestione della terapia farmacologica sono cruciali per pazienti con patologie croniche e acute, specialmente in gravidanza, quando alcune condizioni possono emergere o aggravarsi. La vaccinazione, ad esempio, può prevenire malattie infettive particolarmente rischiose in questo periodo della vita per la madre e per il feto. Analogamente, la terapia farmacologica si dimostra efficace e sicura per il trattamento di disordini della salute ...

Bioconjugations of proteins with 19F and nitroxide tags for in vitro and in cell characterization

This thesis involves the application of various tag topologies, from 19F moieties to nitroxide spin labels. The former were investigated to explore novel alternatives for post-expression covalent modification of tyrosine residues, providing valuable approaches for preparing 19F NMR samples. On the other hand, four different nitroxide spin probes bound to cysteine residues were compared to assess their different behaviour while attached on two different secondary structural elements (α-helix a...

Aerodynamic re-design and optimization of low-pressure turbine stages with artificial intelligence techniques

Il lavoro di tesi ha avuto come obiettivo l'utilizzo di metodi di intelligenza artificiale basati sull'impiego di reti neurali artificiali per il re-design e l'ottimizzazione aerodinamica di moduli di turbina a vapore di bassa pressione

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