Aspetti Genetici ed Epigenetici dell'Infertilità Maschile

Male infertility affects 7% of the general population and the etiology is most frequently related to primary testicular failure. Half of the cases of impaired spermatogenesis still remain unexplained and are referred to as idiopathic male factor infertility; such cases are likely to conceal a not yet identified genetic or epigenetic origin. This thesis aims at studying the genetic and epigenetic aspects of spermatogenesis, with the ultimate scope of identifying novel causes potentially leading to male infertility.