Thiol-ene click chemistry has been applied for obtaining sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors incorporating sugar moieties. Most of these new compounds were moderate CA I inhibitors, effective CA II inhibitors, and low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms CA IX and XII.
Thiol-ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors / Saada, Mohamed-Chiheb; Ombouma, Joanna; Montero, Jean-Louis; Supuran, Claudiu T; Winum, Jean-Yves. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 49:(2013), pp. 5699-5701. [10.1039/c3cc42541j]
Thiol-ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors
SUPURAN, CLAUDIU TRANDAFIR;
2013
Abstract
Thiol-ene click chemistry has been applied for obtaining sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors incorporating sugar moieties. Most of these new compounds were moderate CA I inhibitors, effective CA II inhibitors, and low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms CA IX and XII.
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