Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas

Lounnas, Nadia; Rosilio, Célia; Nebout, Marielle; Mary, Didier; Griessinger, Emmanuel; Neffati, Zouhour; Chiche, Johanna; Spits, Hergen; Hagenbeek, Thijs J.; Asnafi, Vahid; Poulsen, Sally Ann; Supuran, Claudiu Trandafir; Peyron, Jean François; Imbert, Véronique

doi:10.1016/j.canlet.2013.01.020

he membrane-bound carbonic anhydrase isoforms CAIX and CAXII, underpin a pH-regulating system that enables hypoxic tumor cell survival. Here, we observed for the first time an upregulation of CAXII in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LL) cells. First we showed that CAXII is overexpressed in thymocytes from tPTEN-/- mice suffering of T lymphoma and that its pharmacological inhibition decreased cell proliferation and induced apoptosis. The same results were observed with the SupT1 human T cell lymphoma line. In addition we observed an upregulation of CAXII in human T-ALL samples supporting the case that CAXII may represent a new therapeutic target for T-ALL/LL.

Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas / Lounnas, N., Rosilio, C., Nebout, M., Mary, D., Griessinger, E., Neffati, Z., Chiche, J., Spits, H., Hagenbeek, T.J., Asnafi, V., Poulsen, S., Supuran, C.T., Peyron, J., Imbert, V.. - In: CANCER LETTERS. - ISSN 0304-3835. - STAMPA. - 333:(2013), pp. 76-88. [10.1016/j.canlet.2013.01.020]