A series of 2-phenyl- or 3-phenyl piperazines, structurally related to DM235 and DM232, two potent nootropic agents, have been prepared and tested in the mouse passive-avoidance test, to assess their ability to revert scopolamine-induced amnesia. Although the newly synthesized molecules were less potent than the parent compounds, some useful information has been obtained from structure–activity relationships. A small but significant enantioselectivity has been found for the most potent compound 5a.

Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235 / Guandalini, Luca; Martino, Maria Vittoria; Di Cesare Mannelli, Lorenzo; Bartolucci, Gianluca; Melani, Fabrizio; Malik, Ruchi; Dei, Silvia; Floriddia, Elisa; Manetti, Dina; Orlandi, Francesca; Teodori, Elisabetta; Ghelardini, Carla; Romanelli, Maria Novella. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 25:(2015), pp. 1700-1704. [10.1016/j.bmcl.2015.03.009]

Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235

GUANDALINI, LUCA;MARTINO, MARIA VITTORIA;DI CESARE MANNELLI, LORENZO;BARTOLUCCI, GIAN LUCA;MELANI, FABRIZIO;DEI, SILVIA;FLORIDDIA, ELISA;MANETTI, DINA;ORLANDI, FRANCESCA;TEODORI, ELISABETTA;GHELARDINI, CARLA;ROMANELLI, MARIA NOVELLA
2015

Abstract

A series of 2-phenyl- or 3-phenyl piperazines, structurally related to DM235 and DM232, two potent nootropic agents, have been prepared and tested in the mouse passive-avoidance test, to assess their ability to revert scopolamine-induced amnesia. Although the newly synthesized molecules were less potent than the parent compounds, some useful information has been obtained from structure–activity relationships. A small but significant enantioselectivity has been found for the most potent compound 5a.
2015
25
1700
1704
Guandalini, Luca; Martino, Maria Vittoria; Di Cesare Mannelli, Lorenzo; Bartolucci, Gianluca; Melani, Fabrizio; Malik, Ruchi; Dei, Silvia; Floriddia, Elisa; Manetti, Dina; Orlandi, Francesca; Teodori, Elisabetta; Ghelardini, Carla; Romanelli, Maria Novella
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1012479
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