Sorafenib is a kinase inhibitor anticancer drug whose repeated administration causes the onset of a peripheral painful neuropathy. Notably, the efficacy of common analgesic drugs is not adequate and this often leads pre-mature discontinuation of anticancer therapy. The aim of this study was to establish a rat model of sorafenib-induced neuropathic pain, and to assess the effect of the new anti-neuropathic compound dimiracetam in comparison with gabapentin, pregabalin and duloxetine.
A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam / Di Cesare Mannelli, Lorenzo; Maresca, Mario; Farina, Carlo; Scherz, Michael W; Ghelardini, Carla. - In: NEUROTOXICOLOGY. - ISSN 0161-813X. - ELETTRONICO. - 50:(2015), pp. 101-7-107. [10.1016/j.neuro.2015.08.002]
A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam
DI CESARE MANNELLI, LORENZO;MARESCA, MARIO;GHELARDINI, CARLA
2015
Abstract
Sorafenib is a kinase inhibitor anticancer drug whose repeated administration causes the onset of a peripheral painful neuropathy. Notably, the efficacy of common analgesic drugs is not adequate and this often leads pre-mature discontinuation of anticancer therapy. The aim of this study was to establish a rat model of sorafenib-induced neuropathic pain, and to assess the effect of the new anti-neuropathic compound dimiracetam in comparison with gabapentin, pregabalin and duloxetine.
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