One of the most discomfortable dose-limiting adverse reactions of effective drugs for the treatment of solid tumors is a peripheral neuropathy which is the main reason for dose reduction and discontinuation of the therapy. We identified oxidative stress as one target of oxaliplatin toxicity in the search of possible adjuvant therapies to prevent neuropathy and alleviate pain. Therefore, we studied an effective SOD mimetic compound, MnL4, as a possible adjuvant treatment in in vitro cellular cultures and in vivo on a rat model of oxaliplatin-induced neuropathy.

Effect of the SOD mimetic MnL4 on in vitro and in vivo oxaliplatin toxicity: Possible aid in chemotherapy induced neuropathy / Di Cesare Mannelli, Lorenzo; Zanardelli, Matteo; Landini, Ida; Pacini, Alessandra; Ghelardini, Carla; Mini, Enrico; Bencini, Andrea; Valtancoli, Barbara; Failli, Paola. - In: FREE RADICAL BIOLOGY & MEDICINE. - ISSN 0891-5849. - ELETTRONICO. - 93:(2016), pp. 67-76. [10.1016/j.freeradbiomed.2016.01.023]

Effect of the SOD mimetic MnL4 on in vitro and in vivo oxaliplatin toxicity: Possible aid in chemotherapy induced neuropathy

DI CESARE MANNELLI, LORENZO;ZANARDELLI, MATTEO;LANDINI, IDA;PACINI, ALESSANDRA;GHELARDINI, CARLA;MINI, ENRICO;BENCINI, ANDREA;VALTANCOLI, BARBARA;FAILLI, PAOLA
2016

Abstract

One of the most discomfortable dose-limiting adverse reactions of effective drugs for the treatment of solid tumors is a peripheral neuropathy which is the main reason for dose reduction and discontinuation of the therapy. We identified oxidative stress as one target of oxaliplatin toxicity in the search of possible adjuvant therapies to prevent neuropathy and alleviate pain. Therefore, we studied an effective SOD mimetic compound, MnL4, as a possible adjuvant treatment in in vitro cellular cultures and in vivo on a rat model of oxaliplatin-induced neuropathy.
2016
93
67
76
Goal 3: Good health and well-being for people
Di Cesare Mannelli, Lorenzo; Zanardelli, Matteo; Landini, Ida; Pacini, Alessandra; Ghelardini, Carla; Mini, Enrico; Bencini, Andrea; Valtancoli, Barbara; Failli, Paola
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1025987
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