Production of peptides as generic drugs: A patent landscape of octreotide

New low-cost strategies and enhancement of the already described methods to manu- facture peptide molecules on an industrial scale are highly requested, particularly for peptides such as octreotide, which, along with goserelin and leuprolide, dominate the global peptide market. A number of patents related to the production of octreotide can be found, concerning both solution and solid- phase synthesis. Thus, there is a need to revise the existing synthetic approaches in order to organize them in a more comprehensible way.