This project will be devoted to design and synthesis of new fluorescence molecular sensors (chemosensors) for anions in aqueous solution. The targeted species will be inorganic anions of environmental importance, such as halides, phosphates, nitrates, arsenate, etc., or biological substrates having anionic or easy ionizable functions, such as aliphatic and aromatic carboxylic acids, nucleosides and nucleotides. In this respect, we will synthesize new fluorescent polyamine systems, whose protonated forms can be able to bind anions in water, as well as their metal complexes. Both polyammonium and metal based receptors will be tested as selective binding and signaling agents for anionic substrates; this aim is reached when the coordination of the guest changes the fluorescence emission properties of the chemosensor. Selective binding can be achieved by synthesizing receptors containing suitably constructed cleft or cavities to host the anion, in order to maximize the receptoranion interaction. In the course of the development of new metal-based chemosensors for anions, we have in particular investigated the fluorescence emission properties of Zn(II) complexes, whose ability to adapt its coordination environment to bind exogenous substrates is well known. This has lead to the synthesis and characterization of selective fluorescence chemosensors for the recognition of the ion Zn(II). This goal may be also of relevance. Zinc(II) is in fact an essential trace element in all forms of life. Despite its crucial importance in the basic functions maintenance such as proliferation and cell growth, the knowledge of the biological mechanisms involving Zn(II) at a cellular and sub-cellular level are not completely clarified and Zn(II) chemosensors may represent new efficient tools for the analysis of its role in biological processes.

SYNTHESIS OF NEW POLYAMINE RECEPTORS AND THEIR METAL COMPLEXES AS FLUORESCENCE CHEMOSENSORS FOR ANIONS / Bartoli, Francesco. - (2015).

SYNTHESIS OF NEW POLYAMINE RECEPTORS AND THEIR METAL COMPLEXES AS FLUORESCENCE CHEMOSENSORS FOR ANIONS.

BARTOLI, FRANCESCO
2015

Abstract

This project will be devoted to design and synthesis of new fluorescence molecular sensors (chemosensors) for anions in aqueous solution. The targeted species will be inorganic anions of environmental importance, such as halides, phosphates, nitrates, arsenate, etc., or biological substrates having anionic or easy ionizable functions, such as aliphatic and aromatic carboxylic acids, nucleosides and nucleotides. In this respect, we will synthesize new fluorescent polyamine systems, whose protonated forms can be able to bind anions in water, as well as their metal complexes. Both polyammonium and metal based receptors will be tested as selective binding and signaling agents for anionic substrates; this aim is reached when the coordination of the guest changes the fluorescence emission properties of the chemosensor. Selective binding can be achieved by synthesizing receptors containing suitably constructed cleft or cavities to host the anion, in order to maximize the receptoranion interaction. In the course of the development of new metal-based chemosensors for anions, we have in particular investigated the fluorescence emission properties of Zn(II) complexes, whose ability to adapt its coordination environment to bind exogenous substrates is well known. This has lead to the synthesis and characterization of selective fluorescence chemosensors for the recognition of the ion Zn(II). This goal may be also of relevance. Zinc(II) is in fact an essential trace element in all forms of life. Despite its crucial importance in the basic functions maintenance such as proliferation and cell growth, the knowledge of the biological mechanisms involving Zn(II) at a cellular and sub-cellular level are not completely clarified and Zn(II) chemosensors may represent new efficient tools for the analysis of its role in biological processes.
2015
Andrea Bencini
ITALIA
Bartoli, Francesco
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1054958
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