The application of a cell-based growth inhibition on a library of skeletally different glycomimetics allowed for the selection of a hexahydro-2H-furo[3,2-b][1,4]oxazine compound as candidate inhibitors of MDA-MB-231 cell growth. Subsequent synthesis of analogue compounds and preliminary biological studies validated the selection of a valuable hit compound with a novel polyhydroxylated structure for the modulation of the breast carcinoma cell cycle mechanism.
Identification of novel human breast carcinoma (MDA-MB-231) Cell growth modulators from a carbohydrate-based diversity oriented synthesis library / Lenci, Elena; Innocenti, Riccardo; Biagioni, Alessio; Menchi, Gloria; Bianchini, Francesca; Trabocchi, Andrea. - In: MOLECULES. - ISSN 1420-3049. - ELETTRONICO. - 21:(2016), pp. 1405-1423. [10.3390/molecules21101405]
Identification of novel human breast carcinoma (MDA-MB-231) Cell growth modulators from a carbohydrate-based diversity oriented synthesis library
LENCI, ELENA;INNOCENTI, RICCARDO;BIAGIONI, ALESSIO;MENCHI, GLORIA;BIANCHINI, FRANCESCA;TRABOCCHI, ANDREA
2016
Abstract
The application of a cell-based growth inhibition on a library of skeletally different glycomimetics allowed for the selection of a hexahydro-2H-furo[3,2-b][1,4]oxazine compound as candidate inhibitors of MDA-MB-231 cell growth. Subsequent synthesis of analogue compounds and preliminary biological studies validated the selection of a valuable hit compound with a novel polyhydroxylated structure for the modulation of the breast carcinoma cell cycle mechanism.
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