Sepsis is characterized by the loss of the perm-selectivity properties of the glomerular filtration barrier (GFB) with consequent albuminuria. We examined whether the pharmacokinetics-pharmacodynamics (PK/PD) of ceftriaxone (CTX), an extensively protein-bound 3rd generation cephalosporin, is altered during early sepsis and whether an increase in urinary loss of bound-CTX, due to GFB alteration, can occur in this condition.

Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat / Selmi, Valentina; Loriga, Beatrice; Vitali, Luca; Carlucci, Martina; Di Filippo, Alessandro; Carta, Giulio; Sgambati, Eleonora; Tofani, Lorenzo; De Gaudio, Angelo Raffaele; Novelli, Andrea; Adembri, Chiara. - In: JOURNAL OF TRANSLATIONAL MEDICINE. - ISSN 1479-5876. - ELETTRONICO. - 14:(2016), pp. 1-10. [10.1186/s12967-016-1072-9]

Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat

SELMI, VALENTINA;LORIGA, BEATRICE;VITALI, LUCA;CARLUCCI, MARTINA;DI FILIPPO, ALESSANDRO;CARTA, GIULIO ALBERTO;SGAMBATI, ELEONORA;TOFANI, LORENZO;DE GAUDIO, ANGELO RAFFAELE;NOVELLI, ANDREA;ADEMBRI, CHIARA
2016

Abstract

Sepsis is characterized by the loss of the perm-selectivity properties of the glomerular filtration barrier (GFB) with consequent albuminuria. We examined whether the pharmacokinetics-pharmacodynamics (PK/PD) of ceftriaxone (CTX), an extensively protein-bound 3rd generation cephalosporin, is altered during early sepsis and whether an increase in urinary loss of bound-CTX, due to GFB alteration, can occur in this condition.
2016
14
1
10
Selmi, Valentina; Loriga, Beatrice; Vitali, Luca; Carlucci, Martina; Di Filippo, Alessandro; Carta, Giulio; Sgambati, Eleonora; Tofani, Lorenzo; De Gaudio, Angelo Raffaele; Novelli, Andrea; Adembri, Chiara
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1064598
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