This study shows that BCRP is overexpressed and functionally active in the mitochondria of MDR-positive cancer cell lines. However, its presence in the mitochondria of parental drug-sensitive cells suggests that BCRP can be involved in the physiology of cancer cells.
Breast cancer resistance protein (BCRP) expression and activity in mitochondria of different multiple drug-resistant (MDR) cancer cell lines / Mazzanti, R; Solazzo, M; Fantappie, O; D'Amico, M; Sassoli, C; Tani, A; Cipriani, G; Bogani, C; Pestrin, M; Formigli, L. - In: CANCER RESEARCH. - ISSN 0008-5472. - ELETTRONICO. - 69:(2009), pp. ...-....
Breast cancer resistance protein (BCRP) expression and activity in mitochondria of different multiple drug-resistant (MDR) cancer cell lines
MAZZANTI, ROBERTO;SOLAZZO, MICHELA;FANTAPPIE', ORNELLA;D'AMICO, MASSIMO;SASSOLI, CHIARA;TANI, ALESSIA;CIPRIANI, GRETA;BOGANI, COSTANZA;PESTRIN, MARTA;FORMIGLI, LUCIA
2009
Abstract
This study shows that BCRP is overexpressed and functionally active in the mitochondria of MDR-positive cancer cell lines. However, its presence in the mitochondria of parental drug-sensitive cells suggests that BCRP can be involved in the physiology of cancer cells.
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