This study shows that BCRP is overexpressed and functionally active in the mitochondria of MDR-positive cancer cell lines. However, its presence in the mitochondria of parental drug-sensitive cells suggests that BCRP can be involved in the physiology of cancer cells.

Breast cancer resistance protein (BCRP) expression and activity in mitochondria of different multiple drug-resistant (MDR) cancer cell lines / Mazzanti, R; Solazzo, M; Fantappie, O; D'Amico, M; Sassoli, C; Tani, A; Cipriani, G; Bogani, C; Pestrin, M; Formigli, L. - In: CANCER RESEARCH. - ISSN 0008-5472. - ELETTRONICO. - 69(2009), pp. ...-....

Breast cancer resistance protein (BCRP) expression and activity in mitochondria of different multiple drug-resistant (MDR) cancer cell lines

MAZZANTI, ROBERTO;SOLAZZO, MICHELA;FANTAPPIE', ORNELLA;D'AMICO, MASSIMO;SASSOLI, CHIARA;TANI, ALESSIA;CIPRIANI, GRETA;BOGANI, COSTANZA;PESTRIN, MARTA;FORMIGLI, LUCIA
2009

Abstract

This study shows that BCRP is overexpressed and functionally active in the mitochondria of MDR-positive cancer cell lines. However, its presence in the mitochondria of parental drug-sensitive cells suggests that BCRP can be involved in the physiology of cancer cells.
Mazzanti, R; Solazzo, M; Fantappie, O; D'Amico, M; Sassoli, C; Tani, A; Cipriani, G; Bogani, C; Pestrin, M; Formigli, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1077454
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