Brain histamine modulates inhibitory-avoidance memory recall by activating H1 receptors in hippocampal CA1

Memory includes acquisition, consolidation and recall. Retrieval is the only measure of memory but little is known about its mechanisms. Histaminergic neurons are located in the tuberomamillary nucleus, send projections to the whole brain and regulate different types of memory. Here we study the involvement of brain histamine (HA) in inhibi- tory avoidance (IA) memory retrieval, which brain areas are involved, which HA receptor mediates HA action and the biochemical substrates required.