Oleoy- lethanolamide (OEA) exerts an antidepressant-like effect. We previously have observed that neuronal histamine (HA) participates to OEA-induced central effects. Thus, we investigated if brain HA is also required for OEA-induced antidepressant-like effect in mice using the Tail Suspension Test (TST), a classical behavioural paradigm of antide- pressant-like activity.
Lack of antidepressant-like effect of oleoylethanolamide in histamine-deficient mice parallels reduced hippocampal and cortical CREB phosphorylation / Costa, A.; Mannelli, L. D. C.; Ghelardini, C.; Blandina, P.; Passani, M. B.; Provensi, G.. - In: INFLAMMATION RESEARCH. - ISSN 1023-3830. - STAMPA. - 65:(2016), pp. 21-21.
Lack of antidepressant-like effect of oleoylethanolamide in histamine-deficient mice parallels reduced hippocampal and cortical CREB phosphorylation
COSTA, ALESSIA;GHELARDINI, CARLA;BLANDINA, PATRIZIO;PASSANI, MARIA BEATRICE;PROVENSI, GUSTAVO
2016
Abstract
Oleoy- lethanolamide (OEA) exerts an antidepressant-like effect. We previously have observed that neuronal histamine (HA) participates to OEA-induced central effects. Thus, we investigated if brain HA is also required for OEA-induced antidepressant-like effect in mice using the Tail Suspension Test (TST), a classical behavioural paradigm of antide- pressant-like activity.
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