Key factors driving eating behaviour are appetite and satiety that are controlled by central neurotransmitter sys- tems and peripheral stimuli. The brain histamine (HA) system elicits a hypophagic effect activating H1R in restricted hypothalamic regions. Oleoylethanolamide (OEA) is released by enterocytes in response to dietary fat intake and indirectly signals satiety to hypothalamic nuclei. Systemic administration of OEA induces neurons to pro- duce oxytocin in the periventricular nucleus (PVN) and sopraoptic nucleus (SON) that in turn mediates the ano- rexant effect of OEA.
Role of central histaminergic system in the anorexiant effect of oleoylethanolamide: a neuroanatomical study / Fabbri, R.; Umehara, H.; Romano, A.; Gaetani, S.; Provensi, G.; Blandina, P.; Passani, M.B.. - In: INFLAMMATION RESEARCH. - ISSN 1023-3830. - STAMPA. - 63:(2014), pp. 31-31.
Role of central histaminergic system in the anorexiant effect of oleoylethanolamide: a neuroanatomical study
FABBRI, ROBERTA;PROVENSI, GUSTAVO;BLANDINA, PATRIZIO;PASSANI, MARIA BEATRICE
2014
Abstract
Key factors driving eating behaviour are appetite and satiety that are controlled by central neurotransmitter sys- tems and peripheral stimuli. The brain histamine (HA) system elicits a hypophagic effect activating H1R in restricted hypothalamic regions. Oleoylethanolamide (OEA) is released by enterocytes in response to dietary fat intake and indirectly signals satiety to hypothalamic nuclei. Systemic administration of OEA induces neurons to pro- duce oxytocin in the periventricular nucleus (PVN) and sopraoptic nucleus (SON) that in turn mediates the ano- rexant effect of OEA.
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