Bacteria encode carbonic anhydrases (CAs, EC 4.2.1.1) belonging to three different genetic families, the α-, β-, and γ-classes. By equilibrating CO₂ and bicarbonate, these metalloenzymes interfere with pH regulation and other crucial physiological processes of these organisms. The detailed investigations of many such enzymes from pathogenic and non-pathogenic bacteria afford the opportunity to design both novel therapeutic agents, as well as biomimetic processes, for example, for CO₂ capture. Investigation of bacterial CA inhibitors and activators may be relevant for finding antibiotics with a new mechanism of action.
An Overview of the Bacterial Carbonic Anhydrases / Supuran, Claudiu T; Capasso, Clemente. - In: METABOLITES. - ISSN 2218-1989. - ELETTRONICO. - 7:(2017), pp. 1-19. [10.3390/metabo7040056]
An Overview of the Bacterial Carbonic Anhydrases
Supuran, Claudiu T
;
2017
Abstract
Bacteria encode carbonic anhydrases (CAs, EC 4.2.1.1) belonging to three different genetic families, the α-, β-, and γ-classes. By equilibrating CO₂ and bicarbonate, these metalloenzymes interfere with pH regulation and other crucial physiological processes of these organisms. The detailed investigations of many such enzymes from pathogenic and non-pathogenic bacteria afford the opportunity to design both novel therapeutic agents, as well as biomimetic processes, for example, for CO₂ capture. Investigation of bacterial CA inhibitors and activators may be relevant for finding antibiotics with a new mechanism of action.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.