Neuronal histamine and the memory of emotionally salient events

In this review, we describe the experimental paradigms used in preclinical studies to unravel the histaminergic brain circuits that modulate the formation and retrieval of memories associated with aversive events. Emotionally arousing events, especially bad ones, are remembered more accurately, clearly and for longer periods of time than neutral ones. Maladaptive elaborations of these memories may eventually constitute the basis of psychiatric disorders such as generalized anxiety, obsessive-compulsive disorders, post-traumatic stress disorder. A better understanding of the role of the histaminergic system in learning and memory, has not only a theoretical significance, but also a translational value. Ligands of histamine receptors are among the most used drugs worldwide, hence understanding the impact of these compounds on learning and memory may help improve their pharmacological profile and unravel unexplored therapeutic applications.