Several behavioural tests have been developed to study and measure emotionally charged or emotionally neutral memories and how these may be affected by pharmacological, dietary or environmental manipulations. In this review, we describe the experimental paradigms used in preclinical studies to unravel the brain circuits involved in the recognition and memorisation of environmentally salient stimuli devoid of strong emotional value. In particular, we focus on the modulatory role of the brain histaminergic system in the elaboration of recognition memory that is based on the judgment of the prior occurrence of an event and it is believed to be a critical component of human declarative memory. The review also addresses questions that may help improve the treatment of impaired declarative memory described in several affective and neuropsychiatric disorders such as ADHD, Alzheimer's disease, and major neurocognitive disorder.

Brain histamine modulates recognition memory; possible implications in major cognitive disorders / Gustavo Provensi, Alessia Costa, Ivan Izquierdo, Patrizio Blandina, Maria Beatrice Passani. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - STAMPA. - 177:(2020), pp. 539-556. [10.1111/bph.14478]

Brain histamine modulates recognition memory; possible implications in major cognitive disorders

Gustavo Provensi;Alessia Costa;Patrizio Blandina;Maria Beatrice Passani
2020

Abstract

Several behavioural tests have been developed to study and measure emotionally charged or emotionally neutral memories and how these may be affected by pharmacological, dietary or environmental manipulations. In this review, we describe the experimental paradigms used in preclinical studies to unravel the brain circuits involved in the recognition and memorisation of environmentally salient stimuli devoid of strong emotional value. In particular, we focus on the modulatory role of the brain histaminergic system in the elaboration of recognition memory that is based on the judgment of the prior occurrence of an event and it is believed to be a critical component of human declarative memory. The review also addresses questions that may help improve the treatment of impaired declarative memory described in several affective and neuropsychiatric disorders such as ADHD, Alzheimer's disease, and major neurocognitive disorder.
2020
177
539
556
Goal 3: Good health and well-being for people
Gustavo Provensi, Alessia Costa, Ivan Izquierdo, Patrizio Blandina, Maria Beatrice Passani
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1133242
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