BACKGROUND AND PURPOSE: In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made. PATIENTS AND METHODS: Heart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD. RESULTS: Mean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97. CONCLUSION: Results showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial.

Assessment of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant radiotherapy: Quality assessment within a randomized phase III trial testing a cardioprotective treatment strategy (SAFE-2014) / Francolini, Giulio; Desideri, Isacco*; Meattini, Icro; Becherini, Carlotta; Terziani, Francesca; Olmetto, Emanuela; Delli Paoli, Camilla; Pezzulla, Donato; Loi, Mauro; Bonomo, Pierluigi; Greto, Daniela; Calusi, Silvia; Casati, Marta; Pallotta, Stefania; Livi, Lorenzo. - In: STRAHLENTHERAPIE UND ONKOLOGIE. - ISSN 0179-7158. - ELETTRONICO. - (2018), pp. 0-0. [10.1007/s00066-018-1388-x]

Assessment of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant radiotherapy: Quality assessment within a randomized phase III trial testing a cardioprotective treatment strategy (SAFE-2014)

Francolini, Giulio;Desideri, Isacco
;
Meattini, Icro;BECHERINI, CARLOTTA;TERZIANI, FRANCESCA;OLMETTO, EMANUELA;DELLI PAOLI, CAMILLA;PEZZULLA, DONATO;Loi, Mauro;Bonomo, Pierluigi;Greto, Daniela;Calusi, Silvia;Casati, Marta;Pallotta, Stefania;Livi, Lorenzo
2018

Abstract

BACKGROUND AND PURPOSE: In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made. PATIENTS AND METHODS: Heart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD. RESULTS: Mean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97. CONCLUSION: Results showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial.
2018
0
0
Francolini, Giulio; Desideri, Isacco*; Meattini, Icro; Becherini, Carlotta; Terziani, Francesca; Olmetto, Emanuela; Delli Paoli, Camilla; Pezzulla, Do...espandi
File in questo prodotto:
File Dimensione Formato  
2018_Francolini et al_Sthralen.pdf

Accesso chiuso

Descrizione: Paper
Tipologia: Pdf editoriale (Version of record)
Licenza: Tutti i diritti riservati
Dimensione 699.78 kB
Formato Adobe PDF
699.78 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1146272
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 5
social impact