Despite major advances in cardiovascular medicine, heart disease remains a leading cause of death worldwide. However, the field of tissue engineering has been growing exponentially in the last decade and restoring heart functionality is now an affordable target; yet, new materials are still needed for effectively provide rapid and long-lasting interventions. Liquid Crystalline Elastomers (LCEs) are biocompatible polymers able to reversibly change shape in response to a given stimulus, and generate movement. Once stimulated, LCEs can produce tension or movement like a muscle. However, so far their application in biology was limited by a slow response time and a modest possibility to modulate tension levels during activation.

Development of Light-Responsive Liquid Crystalline Elastomers to Assist Cardiac Contraction / Ferrantini, Cecilia; Pioner, Josè Manuel; Martella, Daniele; Coppini, Raffaele; Piroddi, Nicoletta; Paoli, Paolo; Calamai, Martino; Pavone, Francesco; Wiersma, Diederik Sybolt; Tesi, Chiara; Cerbai, Elisabetta; Poggesi, Corrado; Sacconi, Leonardo; Parmeggiani, Camilla. - In: CIRCULATION RESEARCH. - ISSN 0009-7330. - ELETTRONICO. - 124:(2019), pp. 44-54. [10.1161/CIRCRESAHA.118.313889]

Development of Light-Responsive Liquid Crystalline Elastomers to Assist Cardiac Contraction

Ferrantini, Cecilia
;
Pioner, Josè Manuel;Martella, Daniele;Coppini, Raffaele;Piroddi, Nicoletta;Paoli, Paolo;Calamai, Martino;Pavone, Francesco;Wiersma, Diederik Sybolt;Tesi, Chiara;Cerbai, Elisabetta;Poggesi, Corrado;Sacconi, Leonardo;Parmeggiani, Camilla
2019

Abstract

Despite major advances in cardiovascular medicine, heart disease remains a leading cause of death worldwide. However, the field of tissue engineering has been growing exponentially in the last decade and restoring heart functionality is now an affordable target; yet, new materials are still needed for effectively provide rapid and long-lasting interventions. Liquid Crystalline Elastomers (LCEs) are biocompatible polymers able to reversibly change shape in response to a given stimulus, and generate movement. Once stimulated, LCEs can produce tension or movement like a muscle. However, so far their application in biology was limited by a slow response time and a modest possibility to modulate tension levels during activation.
2019
124
44
54
Goal 3: Good health and well-being for people
Ferrantini, Cecilia; Pioner, Josè Manuel; Martella, Daniele; Coppini, Raffaele; Piroddi, Nicoletta; Paoli, Paolo; Calamai, Martino; Pavone, Francesco; Wiersma, Diederik Sybolt; Tesi, Chiara; Cerbai, Elisabetta; Poggesi, Corrado; Sacconi, Leonardo; Parmeggiani, Camilla
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1150895
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