A series of cis/trans ester isomers, that showed high efficacy to reverse the acquired resistance of cancer cells during chemotherapeutic therapy was studied as candidate drugs. In order to evaluate their stability in human plasma, a liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed together with a mathematical algorithm, that is able to identify the isomers present in analyzed samples, without their chromatographic separation.
ERMS EXPERIMENTS FOR RESOLUTION OF ISOBARIC COMPOUNDS: A CASE OF CIS/TRANS ISOMERISM / Laura Braconi; Marta Menicatti; Silvia Dei; Elisabetta Teodori; Gian Luca Bartolucci. - ELETTRONICO. - (2018), pp. 840-841. (Intervento presentato al convegno XXII International Mass Spectrometry Conference tenutosi a Florence (Italy) nel August 26-31, 2018).
ERMS EXPERIMENTS FOR RESOLUTION OF ISOBARIC COMPOUNDS: A CASE OF CIS/TRANS ISOMERISM
Laura Braconi;Marta Menicatti;Silvia Dei;Elisabetta Teodori;Gian Luca Bartolucci
2018
Abstract
A series of cis/trans ester isomers, that showed high efficacy to reverse the acquired resistance of cancer cells during chemotherapeutic therapy was studied as candidate drugs. In order to evaluate their stability in human plasma, a liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed together with a mathematical algorithm, that is able to identify the isomers present in analyzed samples, without their chromatographic separation.
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