Mechanisms leading to preterm premature rupture of membranes (PPROM) remain incompletely defined. Based on the elevated occurrence of PPROM in twin gestations and recent studies of the involvement of insulin-like growth factor binding protein-1 (IGFBP-1) in the inhibition of collagen production we hypothesized that serum IGFBP-1 levels might be predictive of susceptibility to PPROM in women with twins.
Insulin-like growth factor binding protein-1 predicts preterm premature rupture of membranes in twin pregnancies / Sisti, Giovanni; Paccosi, Sara; Parenti, Astrid; Seravalli, Viola; Di Tommaso, Mariarosaria; Witkin, Steven S. - In: ARCHIVES OF GYNECOLOGY AND OBSTETRICS. - ISSN 0932-0067. - ELETTRONICO. - (2019), pp. 0-0. [10.1007/s00404-019-05214-9]
Insulin-like growth factor binding protein-1 predicts preterm premature rupture of membranes in twin pregnancies
Sisti, Giovanni;Paccosi, Sara;Parenti, Astrid;Seravalli, Viola;Di Tommaso, Mariarosaria;
2019
Abstract
Mechanisms leading to preterm premature rupture of membranes (PPROM) remain incompletely defined. Based on the elevated occurrence of PPROM in twin gestations and recent studies of the involvement of insulin-like growth factor binding protein-1 (IGFBP-1) in the inhibition of collagen production we hypothesized that serum IGFBP-1 levels might be predictive of susceptibility to PPROM in women with twins.
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