A new series of β-aminochalcogenides were designed and synthesized to identify new carbonic anhydrase activator (CAA) agents as novel tools for the management of several neurodegenerative and metabolic disorders which represent a clinical challenge without effective therapies available. Some β-aminoselenides and β-aminotellurides showed effective CA activating effects and a potent antioxidant activity. CAAs may have applications for memory therapy and CA deficiency syndromes.
Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators / Damiano Tanini, Antonella Capperucci, Claudiu T. Supuran, Andrea Angeli. - In: BIOORGANIC CHEMISTRY. - ISSN 0045-2068. - ELETTRONICO. - 87:(2019), pp. 516-523. [10.1016/j.bioorg.2019.03.062]
Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators
Damiano Tanini;Antonella Capperucci;Claudiu T. Supuran
;Andrea Angeli
2019
Abstract
A new series of β-aminochalcogenides were designed and synthesized to identify new carbonic anhydrase activator (CAA) agents as novel tools for the management of several neurodegenerative and metabolic disorders which represent a clinical challenge without effective therapies available. Some β-aminoselenides and β-aminotellurides showed effective CA activating effects and a potent antioxidant activity. CAAs may have applications for memory therapy and CA deficiency syndromes.
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Bioorg. Chem. 2019-pag.516_ms-Revised.pdf
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