The synthesis of new 3-alkyloxycarbonyl-, 3-cyclo-alkyloxycarbonyl-, 3- aryloxycarbonyl derivatives of pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides and their binding affinities at the central benzodiazepine receptor (BZR) are reported. The 3-propynyl ester 10 and the 3-benzyl ester 16, having the best affinity values, were chosen for in vivo testing.
Chemistry of Substituted Pyrazolo[1,5-a]pyrimidines. Part 5. 7-Oxo-6-[bpyrazol-3’(5’)-yl]-4,7-dihydropyrazolo[1,5-a]pyrimidines from 6-Ethoxycarbonyl-7-(2-dimethylaminovinyl)-pyrazolo[1,5-a]pyrimidines: Elucidation of the Reaction Mechanism through NMR Spectroscopy and X-Ray Diffraction Analysis / CHIMICHI, S.; BRUNI, F.; COSIMELLI, B.; SELLERI, S.; VALLE, G.. - In: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS II. - ISSN 0300-9580. - ELETTRONICO. - ..:(1996), pp. 1147-1152. [10.1039/P29960001147]
Chemistry of Substituted Pyrazolo[1,5-a]pyrimidines. Part 5. 7-Oxo-6-[bpyrazol-3’(5’)-yl]-4,7-dihydropyrazolo[1,5-a]pyrimidines from 6-Ethoxycarbonyl-7-(2-dimethylaminovinyl)-pyrazolo[1,5-a]pyrimidines: Elucidation of the Reaction Mechanism through NMR Spectroscopy and X-Ray Diffraction Analysis
CHIMICHI, S.;BRUNI, F.;SELLERI, S.;
1996
Abstract
The synthesis of new 3-alkyloxycarbonyl-, 3-cyclo-alkyloxycarbonyl-, 3- aryloxycarbonyl derivatives of pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides and their binding affinities at the central benzodiazepine receptor (BZR) are reported. The 3-propynyl ester 10 and the 3-benzyl ester 16, having the best affinity values, were chosen for in vivo testing.
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