Our results demonstrate that cfDNA mutation screening with a commercial kit allows the detection of both germline and somatic BRCA1/2 mutations at the same time, permitting to monitor the presence of possible reverse mutations, which could affect the efficacy of PARP inhibitors.
Detection of BRCA1 and BRCA2 variants in circulating free DNA by using a commercial kit / Capone, GL; Putignano, AL; Patuelli, A; Paganini, I; Sestini, R; Gensini, F; Marozza, A; Porfirio, B; Papi, L. - In: EUROPEAN JOURNAL OF HUMAN GENETICS. - ISSN 1018-4813. - STAMPA. - 27:(2019), pp. 399-400.
Detection of BRCA1 and BRCA2 variants in circulating free DNA by using a commercial kit
Capone, GL;Putignano, AL;Patuelli, A;Paganini, I;Sestini, R;Gensini, F;Marozza, A;Porfirio, B;Papi, L
2019
Abstract
Our results demonstrate that cfDNA mutation screening with a commercial kit allows the detection of both germline and somatic BRCA1/2 mutations at the same time, permitting to monitor the presence of possible reverse mutations, which could affect the efficacy of PARP inhibitors.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
