BACKGROUND: The aim of this study was to assess prognostic stratification in patients admitted in two Italian Emergency-Department High-Dependency Units (ED-HDU). METHODS: From June 2014, to July 2016, we recorded all patients admitted in the ED-HDU of the Careggi University Hospital and the Vittorio Emanuele University Hospital in a standardized database. Charlson Index and SOFA Score were calculated to evaluate comorbidity burden and severity of organ dysfunction. End-points were HDU and in-hospital mortality rate and need of Intensive Care Unit (ICU) transfer. RESULTS: The overall number of patients admitted in the two Units was 3311, 1822 in Florence and 1489 in Catania. HDU mortality rate was 5% (N.=171); compared with survivors, non-survivors showed a higher SOFA Score (10.0+/-4.2 vs. 3.5+/-2.9, P<0.001) and a higher number of organ dysfunctions (1.6+/-0.9 vs. 0.6+/-0.8, P<0.001). All patients with a SOFA Score in the first and second quartile survived HDU admission (only two non-survivors among patients in the second quartile), while mortality was disproportionally high in the group with a score value in the fourth quartile (0%, 0.2%, 3% and 14%, P<0.001). Presence and number of organ failure, as well as SOFA Score (5.6+/-4.0 vs. 3.4+/-2.8, P<0.001), were significantly higher in patients transferred to ICU than in those admitted in an ordinary ward or discharged. A higher SOFA Score (RR 1.55, 95% CI: 1.47-1.63, P<0.001) was associated with an increased HDU mortality, independent of age and Charlson Index. CONCLUSIONS: SOFA Score showed a good discrimination ability for both HDU - mortality and indication to increase the level of care.

SOFA Score prognostic performance among patients admitted to High-Dependency Units / Innocenti F.; Caldi F.; Tassinari I.; Meo F.; Gandini A.; Noto P.; Mangano G.; Carpinteri G.; Pini R.. - In: MINERVA ANESTESIOLOGICA. - ISSN 0375-9393. - STAMPA. - 85:(2019), pp. 1080-1088. [10.23736/S0375-9393.19.13543-2]

SOFA Score prognostic performance among patients admitted to High-Dependency Units

Innocenti F.
;
Caldi F.;Tassinari I.;Meo F.;Gandini A.;Pini R.
2019

Abstract

BACKGROUND: The aim of this study was to assess prognostic stratification in patients admitted in two Italian Emergency-Department High-Dependency Units (ED-HDU). METHODS: From June 2014, to July 2016, we recorded all patients admitted in the ED-HDU of the Careggi University Hospital and the Vittorio Emanuele University Hospital in a standardized database. Charlson Index and SOFA Score were calculated to evaluate comorbidity burden and severity of organ dysfunction. End-points were HDU and in-hospital mortality rate and need of Intensive Care Unit (ICU) transfer. RESULTS: The overall number of patients admitted in the two Units was 3311, 1822 in Florence and 1489 in Catania. HDU mortality rate was 5% (N.=171); compared with survivors, non-survivors showed a higher SOFA Score (10.0+/-4.2 vs. 3.5+/-2.9, P<0.001) and a higher number of organ dysfunctions (1.6+/-0.9 vs. 0.6+/-0.8, P<0.001). All patients with a SOFA Score in the first and second quartile survived HDU admission (only two non-survivors among patients in the second quartile), while mortality was disproportionally high in the group with a score value in the fourth quartile (0%, 0.2%, 3% and 14%, P<0.001). Presence and number of organ failure, as well as SOFA Score (5.6+/-4.0 vs. 3.4+/-2.8, P<0.001), were significantly higher in patients transferred to ICU than in those admitted in an ordinary ward or discharged. A higher SOFA Score (RR 1.55, 95% CI: 1.47-1.63, P<0.001) was associated with an increased HDU mortality, independent of age and Charlson Index. CONCLUSIONS: SOFA Score showed a good discrimination ability for both HDU - mortality and indication to increase the level of care.
2019
85
1080
1088
Goal 3: Good health and well-being for people
Innocenti F.; Caldi F.; Tassinari I.; Meo F.; Gandini A.; Noto P.; Mangano G.; Carpinteri G.; Pini R.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1181089
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