Purposes: To explore OCT-A abnormalities in CHM carriers Methods: CHM carriers and age-matched controls were consecutively enrolled at the Eye Clinic in Florence. All patients underwent a complete ophthalmic examination, fundus photography, fundus autofluorescence (FAF) and OCT examinations. OCT-A images of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris slab (CC) were acquired and analyzed using ImageJ software to detect and quantify vascular density. Results: Six patients (12 eyes) and 8 age-matched controls (16 eyes) were included in our study. The mean age was 45.5 ± 16.3 years (range 15-61) for the CHM carriers and 46.6 ± 12.2 (range 18-54) for controls. All CHM carriers showed fundus abnormalities. The detected mean central retinal thickness (CRT) (220 ± 18.34 vs 227± 15.46; p=0.342) and choroidal central thickness (CCT) (271±54.28 vs 275 ± 38.36; p=0.760) did not differ between the carrier and the control group, respectively. Quantitative analysis of the inner retinal vasculature disclosed no significant difference of both SCP (p=0.437) and DCP (p=0.859) vessel density compared to the control group. Of note, a mild reduction on the vascular flow of the CC could be detected in the carrier group compared to the control group (78.896 ± 13.972 vs 80.008 ± 10.862; p=0.045). Conclusions: OCT-A allows us to underline the role of the retinal pigment epithelium in the CHM pathophysiology. Central inner retinal and choriocapillaris vascularization were preserved although the RPE was always involved in the CHM carrier: this could support a secondary role of vascular impairment in the natural history of the disease.
Optical Coherence Tomography Angiography (OCT-A) in Choroideremia (CHM) carriers / Vittoria Murro, Dario Pasquale Mucciolo, Dario Giorgio, Andrea Sodi, Ilaria Passerini, Gianni Virgili, Stanislao Rizzo. - In: OPHTHALMIC GENETICS. - ISSN 1381-6810. - ELETTRONICO. - (2020), pp. 1-8.
Optical Coherence Tomography Angiography (OCT-A) in Choroideremia (CHM) carriers
Vittoria Murro;Dario Pasquale Mucciolo;Dario Giorgio;Andrea Sodi;Ilaria Passerini;Gianni Virgili;Stanislao Rizzo
2020
Abstract
Purposes: To explore OCT-A abnormalities in CHM carriers Methods: CHM carriers and age-matched controls were consecutively enrolled at the Eye Clinic in Florence. All patients underwent a complete ophthalmic examination, fundus photography, fundus autofluorescence (FAF) and OCT examinations. OCT-A images of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris slab (CC) were acquired and analyzed using ImageJ software to detect and quantify vascular density. Results: Six patients (12 eyes) and 8 age-matched controls (16 eyes) were included in our study. The mean age was 45.5 ± 16.3 years (range 15-61) for the CHM carriers and 46.6 ± 12.2 (range 18-54) for controls. All CHM carriers showed fundus abnormalities. The detected mean central retinal thickness (CRT) (220 ± 18.34 vs 227± 15.46; p=0.342) and choroidal central thickness (CCT) (271±54.28 vs 275 ± 38.36; p=0.760) did not differ between the carrier and the control group, respectively. Quantitative analysis of the inner retinal vasculature disclosed no significant difference of both SCP (p=0.437) and DCP (p=0.859) vessel density compared to the control group. Of note, a mild reduction on the vascular flow of the CC could be detected in the carrier group compared to the control group (78.896 ± 13.972 vs 80.008 ± 10.862; p=0.045). Conclusions: OCT-A allows us to underline the role of the retinal pigment epithelium in the CHM pathophysiology. Central inner retinal and choriocapillaris vascularization were preserved although the RPE was always involved in the CHM carrier: this could support a secondary role of vascular impairment in the natural history of the disease.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.