Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes

Yi, G.; Wierenga, A. T. J.; Petraglia, F.; Narang, P.; Janssen-Megens, E. M.; Mandoli, A.; Merkel, A.; Berentsen, K.; Kim, B.; Matarese, F.; Singh, A. A.; Habibi, E.; Prange, K. H. M.; Mulder, A. B.; Jansen, J. H.; Clarke, L.; Heath, S.; Van Der Reijden, B. A.; Flicek, P.; Yaspo, M. -L.; Gut, I.; Bock, C.; Schuringa, J. J.; Altucci, L.; Vellenga, E.; Stunnenberg, H. G.; Martens, J. H. A.

doi:10.1016/j.celrep.2018.12.098

Yi et al. find that despite pronounced genetic heterogeneity, integrative chromatin profiling converges acute myeloid leukemia (AML) patients with stemness-attributed similarity into the same subtype. The study provides a comprehensive resource for investigating the molecular basis and underpinnings of AML progression in primary samples.

Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes / Yi G., Wierenga A.T.J., Petraglia F., Narang P., Janssen-Megens E.M., Mandoli A., Merkel A., Berentsen K., Kim B., Matarese F., Singh A.A., Habibi E., Prange K.H.M., Mulder A.B., Jansen J.H., Clarke L., Heath S., van der Reijden B.A., Flicek P., Yaspo M.-L., et al.. - In: CELL REPORTS. - ISSN 2211-1247. - ELETTRONICO. - 26:(2019), pp. 1059-1069.e6. [10.1016/j.celrep.2018.12.098]