Yi et al. find that despite pronounced genetic heterogeneity, integrative chromatin profiling converges acute myeloid leukemia (AML) patients with stemness-attributed similarity into the same subtype. The study provides a comprehensive resource for investigating the molecular basis and underpinnings of AML progression in primary samples.
Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes / Yi G.; Wierenga A.T.J.; Petraglia F.; Narang P.; Janssen-Megens E.M.; Mandoli A.; Merkel A.; Berentsen K.; Kim B.; Matarese F.; Singh A.A.; Habibi E.; Prange K.H.M.; Mulder A.B.; Jansen J.H.; Clarke L.; Heath S.; van der Reijden B.A.; Flicek P.; Yaspo M.-L.; Gut I.; Bock C.; Schuringa J.J.; Altucci L.; Vellenga E.; Stunnenberg H.G.; Martens J.H.A.. - In: CELL REPORTS. - ISSN 2211-1247. - ELETTRONICO. - 26:(2019), pp. 1059-1069.e6. [10.1016/j.celrep.2018.12.098]
Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes
Yi G.;Petraglia F.;Mandoli A.;Merkel A.;Kim B.;Altucci L.;
2019
Abstract
Yi et al. find that despite pronounced genetic heterogeneity, integrative chromatin profiling converges acute myeloid leukemia (AML) patients with stemness-attributed similarity into the same subtype. The study provides a comprehensive resource for investigating the molecular basis and underpinnings of AML progression in primary samples.
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