Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent

Mazzoni, Alessio; Salvati, Lorenzo; Maggi, Laura; Capone, Manuela; Vanni, Anna; Spinicci, Michele; Mencarini, Jessica; Caporale, Roberto; Peruzzi, Benedetta; Antonelli, Alberto; Trotta, Michele; Zammarchi, Lorenzo; Ciani, Luca; Gori, Leonardo; Lazzeri, Chiara; Matucci, Andrea; Vultaggio, Alessandra; Rossi, Oliviero; Almerigogna, Fabio; Parronchi, Paola; Fontanari, Paolo; Lavorini, Federico; Peris, Adriano; Rossolini, Gian Maria; Bartoloni, Alessandro; Romagnani, Sergio; Liotta, Francesco; Annunziato, Francesco; Cosmi, Lorenzo

doi:10.1172/JCI138554

Coronavirus disease 19 (COVID-19) is an emerging infectious disease caused by SARS-CoV-2. Anti-viral immune response is crucial to achieve pathogen clearance, however in some patients an excessive and aberrant host immune response can lead to an acute respiratory distress syndrome. The comprehension of the mechanisms that regulate pathogen elimination, immunity, and pathology is essential to better characterize disease progression and widen the spectrum of therapeutic options.

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent / Mazzoni, Alessio; Salvati, Lorenzo; Maggi, Laura; Capone, Manuela; Vanni, Anna; Spinicci, Michele; Mencarini, Jessica; Caporale, Roberto; Peruzzi, Benedetta; Antonelli, Alberto; Trotta, Michele; Zammarchi, Lorenzo; Ciani, Luca; Gori, Leonardo; Lazzeri, Chiara; Matucci, Andrea; Vultaggio, Alessandra; Rossi, Oliviero; Almerigogna, Fabio; Parronchi, Paola; Fontanari, Paolo; Lavorini, Federico; Peris, Adriano; Rossolini, Gian Maria; Bartoloni, Alessandro; Romagnani, Sergio; Liotta, Francesco; Annunziato, Francesco; Cosmi, Lorenzo. - In: THE JOURNAL OF CLINICAL INVESTIGATION. - ISSN 1558-8238. - ELETTRONICO. - (2020), pp. 0-0. [10.1172/JCI138554]