Recent structural studies show distinct morphologies for the fibrils of Aβ(1-42) and Aβ(1-40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1 : 1 mixed fibrillar species, which differs from both pure fibrils. It forms preferentially even when Aβ(1-42) : Aβ(1-40) peptides are mixed in a non-stoichiometric ratio. This journal is
Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils / Cerofolini L., Ravera E., Bologna S., Wiglenda T., Boddrich A., Purfurst B., Benilova I., Korsak M., Gallo G., Rizzo D., Gonnelli L., Fragai M., De Strooper B., Wanker E.E., Luchinat C.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 56:(2020), pp. 8830-8833. [10.1039/d0cc02463e]
Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils
Cerofolini L.;Ravera E.;Bologna S.;Korsak M.;Gallo G.;Rizzo D.;Gonnelli L.;Fragai M.;Luchinat C.
2020
Abstract
Recent structural studies show distinct morphologies for the fibrils of Aβ(1-42) and Aβ(1-40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1 : 1 mixed fibrillar species, which differs from both pure fibrils. It forms preferentially even when Aβ(1-42) : Aβ(1-40) peptides are mixed in a non-stoichiometric ratio. This journal is
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