Recent structural studies show distinct morphologies for the fibrils of Aβ(1-42) and Aβ(1-40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1 : 1 mixed fibrillar species, which differs from both pure fibrils. It forms preferentially even when Aβ(1-42) : Aβ(1-40) peptides are mixed in a non-stoichiometric ratio. This journal is

Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils / Cerofolini L.; Ravera E.; Bologna S.; Wiglenda T.; Boddrich A.; Purfurst B.; Benilova I.; Korsak M.; Gallo G.; Rizzo D.; Gonnelli L.; Fragai M.; De Strooper B.; Wanker E.E.; Luchinat C.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 56:(2020), pp. 8830-8833. [10.1039/d0cc02463e]

Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils

Cerofolini L.;Ravera E.;Bologna S.;Korsak M.;Gallo G.;Rizzo D.;Gonnelli L.;Fragai M.;Luchinat C.
2020

Abstract

Recent structural studies show distinct morphologies for the fibrils of Aβ(1-42) and Aβ(1-40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1 : 1 mixed fibrillar species, which differs from both pure fibrils. It forms preferentially even when Aβ(1-42) : Aβ(1-40) peptides are mixed in a non-stoichiometric ratio. This journal is
2020
56
8830
8833
Goal 3: Good health and well-being for people
Cerofolini L.; Ravera E.; Bologna S.; Wiglenda T.; Boddrich A.; Purfurst B.; Benilova I.; Korsak M.; Gallo G.; Rizzo D.; Gonnelli L.; Fragai M.; De St...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1211078
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