Recent structural studies show distinct morphologies for the fibrils of Aβ(1-42) and Aβ(1-40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1 : 1 mixed fibrillar species, which differs from both pure fibrils. It forms preferentially even when Aβ(1-42) : Aβ(1-40) peptides are mixed in a non-stoichiometric ratio. This journal is
Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils / Cerofolini L.; Ravera E.; Bologna S.; Wiglenda T.; Boddrich A.; Purfurst B.; Benilova I.; Korsak M.; Gallo G.; Rizzo D.; Gonnelli L.; Fragai M.; De Strooper B.; Wanker E.E.; Luchinat C.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 56:(2020), pp. 8830-8833. [10.1039/d0cc02463e]
Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils
Cerofolini L.;Ravera E.;Bologna S.;Korsak M.;Gallo G.;Rizzo D.;Gonnelli L.;Fragai M.;Luchinat C.
2020
Abstract
Recent structural studies show distinct morphologies for the fibrils of Aβ(1-42) and Aβ(1-40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1 : 1 mixed fibrillar species, which differs from both pure fibrils. It forms preferentially even when Aβ(1-42) : Aβ(1-40) peptides are mixed in a non-stoichiometric ratio. This journal is
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