BACKGROUND AND OBJECTIVE: Plaque formation ordinarily takes place in the acute phase of Peyronie's disease. There is no unanimous consent regarding the management of the acute phase of Peyronie's disease. The objective of this study was to evaluate the advantages of using a single intralesional injection of collagenase Clostridium histolyticum in patients with the active phase of Peyronie's disease and to assess its effect on disease progression by reducing penile curvature and ameliorating pain during sexual intercourse.
Efficacy of Collagenase Clostridium histolyticum (Xiapex®) in Patients with the Acute Phase of Peyronie's Disease / Cocci, Andrea; Di Maida, Fabrizio; Russo, Giorgio Ivan; Capogrosso, Paolo; Francesco, Lotti; Rizzo, Michele; Di Mauro, Marina; Salonia, Andrea; Cito, Gianmartin; Falcone, Marco; Romano, Andrea; Polloni, Gaia; Martinez-Salamanca, Juan Ignacio; Fernández-Pascual, Esaù; Minervini, Andrea; Mondaini, Nicola. - In: CLINICAL DRUG INVESTIGATION. - ISSN 1173-2563. - ELETTRONICO. - 40:(2020), pp. 583-588. [10.1007/s40261-020-00916-4]
Efficacy of Collagenase Clostridium histolyticum (Xiapex®) in Patients with the Acute Phase of Peyronie's Disease
Cocci, Andrea;Di Maida, Fabrizio;Francesco, Lotti;Cito, Gianmartin;Romano, Andrea;Minervini, Andrea;Mondaini, Nicola
2020
Abstract
BACKGROUND AND OBJECTIVE: Plaque formation ordinarily takes place in the acute phase of Peyronie's disease. There is no unanimous consent regarding the management of the acute phase of Peyronie's disease. The objective of this study was to evaluate the advantages of using a single intralesional injection of collagenase Clostridium histolyticum in patients with the active phase of Peyronie's disease and to assess its effect on disease progression by reducing penile curvature and ameliorating pain during sexual intercourse.
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